Glaucoma

Gülgün Tezel, Martin B. Wax

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Citations (Scopus)

Abstract

Glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosis of retinal ganglion cells (RGCs) and progressive loss of optic nerve axons result in structural and functional deficits in glaucoma patients. This neurodegenerative disease is indeed a leading cause of blindness in the world. The glaucomatous neurodegenerative environment has been associated with the activation of multiple pathogenic mechanisms for RGC death and axon degeneration. Growing evidence obtained from clinical and experimental studies over the last decade also strongly suggests the involvement of the immune system in this neurodegenerative process. Paradoxically, the roles of the immune system in glaucoma have been described as either neuroprotective or neurodestructive. A balance between beneficial immunity and harmful autoimmune neurodegeneration may ultimately determine the fate of RGCs in response to various stressors in glaucomatous eyes. Based on clinical data in humans, it has been proposed that one form of glaucoma may be an autoimmune neuropathy, in which an individual's immune response facilitates a somatic and/or axonal degeneration of RGCs by the very system which normally serves to protect it against tissue stress.

Original languageEnglish (US)
Title of host publicationChemical Immunology and Allergy
Pages221-227
Number of pages7
Volume92
DOIs
StatePublished - 2007

Publication series

NameChemical Immunology and Allergy
Volume92
ISSN (Print)16602242

Fingerprint

Retinal Ganglion Cells
Glaucoma
Optic Nerve
Neurodegenerative Diseases
Axons
Immune System
Blindness
Immunity
Chronic Disease
Cell Death
Apoptosis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Tezel, G., & Wax, M. B. (2007). Glaucoma. In Chemical Immunology and Allergy (Vol. 92, pp. 221-227). (Chemical Immunology and Allergy; Vol. 92). https://doi.org/10.1159/000099273

Glaucoma. / Tezel, Gülgün; Wax, Martin B.

Chemical Immunology and Allergy. Vol. 92 2007. p. 221-227 (Chemical Immunology and Allergy; Vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tezel, G & Wax, MB 2007, Glaucoma. in Chemical Immunology and Allergy. vol. 92, Chemical Immunology and Allergy, vol. 92, pp. 221-227. https://doi.org/10.1159/000099273
Tezel G, Wax MB. Glaucoma. In Chemical Immunology and Allergy. Vol. 92. 2007. p. 221-227. (Chemical Immunology and Allergy). https://doi.org/10.1159/000099273
Tezel, Gülgün ; Wax, Martin B. / Glaucoma. Chemical Immunology and Allergy. Vol. 92 2007. pp. 221-227 (Chemical Immunology and Allergy).
@inbook{d8c92ea8473e496d8eab069f19465180,
title = "Glaucoma",
abstract = "Glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosis of retinal ganglion cells (RGCs) and progressive loss of optic nerve axons result in structural and functional deficits in glaucoma patients. This neurodegenerative disease is indeed a leading cause of blindness in the world. The glaucomatous neurodegenerative environment has been associated with the activation of multiple pathogenic mechanisms for RGC death and axon degeneration. Growing evidence obtained from clinical and experimental studies over the last decade also strongly suggests the involvement of the immune system in this neurodegenerative process. Paradoxically, the roles of the immune system in glaucoma have been described as either neuroprotective or neurodestructive. A balance between beneficial immunity and harmful autoimmune neurodegeneration may ultimately determine the fate of RGCs in response to various stressors in glaucomatous eyes. Based on clinical data in humans, it has been proposed that one form of glaucoma may be an autoimmune neuropathy, in which an individual's immune response facilitates a somatic and/or axonal degeneration of RGCs by the very system which normally serves to protect it against tissue stress.",
author = "G{\"u}lg{\"u}n Tezel and Wax, {Martin B.}",
year = "2007",
doi = "10.1159/000099273",
language = "English (US)",
isbn = "3805581874",
volume = "92",
series = "Chemical Immunology and Allergy",
pages = "221--227",
booktitle = "Chemical Immunology and Allergy",

}

TY - CHAP

T1 - Glaucoma

AU - Tezel, Gülgün

AU - Wax, Martin B.

PY - 2007

Y1 - 2007

N2 - Glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosis of retinal ganglion cells (RGCs) and progressive loss of optic nerve axons result in structural and functional deficits in glaucoma patients. This neurodegenerative disease is indeed a leading cause of blindness in the world. The glaucomatous neurodegenerative environment has been associated with the activation of multiple pathogenic mechanisms for RGC death and axon degeneration. Growing evidence obtained from clinical and experimental studies over the last decade also strongly suggests the involvement of the immune system in this neurodegenerative process. Paradoxically, the roles of the immune system in glaucoma have been described as either neuroprotective or neurodestructive. A balance between beneficial immunity and harmful autoimmune neurodegeneration may ultimately determine the fate of RGCs in response to various stressors in glaucomatous eyes. Based on clinical data in humans, it has been proposed that one form of glaucoma may be an autoimmune neuropathy, in which an individual's immune response facilitates a somatic and/or axonal degeneration of RGCs by the very system which normally serves to protect it against tissue stress.

AB - Glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosis of retinal ganglion cells (RGCs) and progressive loss of optic nerve axons result in structural and functional deficits in glaucoma patients. This neurodegenerative disease is indeed a leading cause of blindness in the world. The glaucomatous neurodegenerative environment has been associated with the activation of multiple pathogenic mechanisms for RGC death and axon degeneration. Growing evidence obtained from clinical and experimental studies over the last decade also strongly suggests the involvement of the immune system in this neurodegenerative process. Paradoxically, the roles of the immune system in glaucoma have been described as either neuroprotective or neurodestructive. A balance between beneficial immunity and harmful autoimmune neurodegeneration may ultimately determine the fate of RGCs in response to various stressors in glaucomatous eyes. Based on clinical data in humans, it has been proposed that one form of glaucoma may be an autoimmune neuropathy, in which an individual's immune response facilitates a somatic and/or axonal degeneration of RGCs by the very system which normally serves to protect it against tissue stress.

UR - http://www.scopus.com/inward/record.url?scp=33947536616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947536616&partnerID=8YFLogxK

U2 - 10.1159/000099273

DO - 10.1159/000099273

M3 - Chapter

C2 - 17264498

AN - SCOPUS:33947536616

SN - 3805581874

SN - 9783805581875

VL - 92

T3 - Chemical Immunology and Allergy

SP - 221

EP - 227

BT - Chemical Immunology and Allergy

ER -