Glaucoma in patients with corneal endothelial dystrophy

Zahra K. Ali, Jess T. Whitson, V. Vinod Mootha, S. Robert Witherspoon, J. Arun Joseph, Ashley M. Joseph, Linda S. Hynan, H. Dwight Cavanagh

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES:: The prevalence of primary open-angle glaucoma (POAG) in patients with corneal endothelial dystrophy has not been previously studied. Prevalence of POAG in patients with endothelial dystrophy was compared with that in the general population to determine the presence of a relationship between the diseases. DESIGN:: Retrospective case-control study. METHODS:: A study of the prevalence of POAG in 430 eyes of 215 patients with endothelial dystrophy was conducted. Patients followed for less than 6 months were excluded. Relative risk of POAG was calculated using age-and race-matched control data from the Baltimore Eye Survey and the Los Angeles Latino Eye Survey for comparison. Ocular hypertension (OHT) and secondary glaucoma (SG) rates after penetrating keratoplasty (PK) and Descemet stripping endothelial keratoplasty (DSEK) were separately analyzed. RESULTS:: Relative risk of POAG in white, African American, and Hispanic patients with endothelial dystrophy was 0.94, 2.59, and 3.7, respectively (P = 0.89, 95% confidence interval [CI], -0.028 to 0.0289; P = 0.13; 95% CI, 0.011-0.274; P = 0.055; 95% CI, 0.0423-0.356). Relative risk of SG and combined OHT/SG in PK versus DSEK was 4.15 and 1.95 (P < 0.001; 95% CI, 0.0654-0.322; P = 0.005; 95% CI, 0.116-0.332), respectively. No differences in OHT/SG rates were found comparing PK-triple with PK, DSEK-triple with DSEK, and repeat with primary PK or DSEK (P = 0.98; P = 0.62; P = 0.95; P = 0.87), respectively. CONCLUSIONS:: No increased risk of POAG was found in patients with endothelial dystrophy. Increased prevalence of OHT/SG was shown with PK versus DSEK; possible mechanisms include mechanical closure of Schlemms canal by running suture and prolonged steroid use.

Original languageEnglish (US)
Pages (from-to)332-336
Number of pages5
JournalEye and Contact Lens
Volume37
Issue number6
DOIs
StatePublished - Nov 2011

Fingerprint

Descemet Stripping Endothelial Keratoplasty
Penetrating Keratoplasty
Glaucoma
Ocular Hypertension
Confidence Intervals
Hispanic Americans
Baltimore
Los Angeles
African Americans
Sutures
Primary Open Angle Glaucoma
Case-Control Studies
Cross-Sectional Studies
Steroids

Keywords

  • Corneal endothelial dystrophy
  • Fuchs' dystrophy
  • Ocular hypertension
  • Primary open-angle glaucoma
  • Secondary glaucoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Glaucoma in patients with corneal endothelial dystrophy. / Ali, Zahra K.; Whitson, Jess T.; Mootha, V. Vinod; Witherspoon, S. Robert; Joseph, J. Arun; Joseph, Ashley M.; Hynan, Linda S.; Cavanagh, H. Dwight.

In: Eye and Contact Lens, Vol. 37, No. 6, 11.2011, p. 332-336.

Research output: Contribution to journalArticle

Ali, Zahra K. ; Whitson, Jess T. ; Mootha, V. Vinod ; Witherspoon, S. Robert ; Joseph, J. Arun ; Joseph, Ashley M. ; Hynan, Linda S. ; Cavanagh, H. Dwight. / Glaucoma in patients with corneal endothelial dystrophy. In: Eye and Contact Lens. 2011 ; Vol. 37, No. 6. pp. 332-336.
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T1 - Glaucoma in patients with corneal endothelial dystrophy

AU - Ali, Zahra K.

AU - Whitson, Jess T.

AU - Mootha, V. Vinod

AU - Witherspoon, S. Robert

AU - Joseph, J. Arun

AU - Joseph, Ashley M.

AU - Hynan, Linda S.

AU - Cavanagh, H. Dwight

PY - 2011/11

Y1 - 2011/11

N2 - OBJECTIVES:: The prevalence of primary open-angle glaucoma (POAG) in patients with corneal endothelial dystrophy has not been previously studied. Prevalence of POAG in patients with endothelial dystrophy was compared with that in the general population to determine the presence of a relationship between the diseases. DESIGN:: Retrospective case-control study. METHODS:: A study of the prevalence of POAG in 430 eyes of 215 patients with endothelial dystrophy was conducted. Patients followed for less than 6 months were excluded. Relative risk of POAG was calculated using age-and race-matched control data from the Baltimore Eye Survey and the Los Angeles Latino Eye Survey for comparison. Ocular hypertension (OHT) and secondary glaucoma (SG) rates after penetrating keratoplasty (PK) and Descemet stripping endothelial keratoplasty (DSEK) were separately analyzed. RESULTS:: Relative risk of POAG in white, African American, and Hispanic patients with endothelial dystrophy was 0.94, 2.59, and 3.7, respectively (P = 0.89, 95% confidence interval [CI], -0.028 to 0.0289; P = 0.13; 95% CI, 0.011-0.274; P = 0.055; 95% CI, 0.0423-0.356). Relative risk of SG and combined OHT/SG in PK versus DSEK was 4.15 and 1.95 (P < 0.001; 95% CI, 0.0654-0.322; P = 0.005; 95% CI, 0.116-0.332), respectively. No differences in OHT/SG rates were found comparing PK-triple with PK, DSEK-triple with DSEK, and repeat with primary PK or DSEK (P = 0.98; P = 0.62; P = 0.95; P = 0.87), respectively. CONCLUSIONS:: No increased risk of POAG was found in patients with endothelial dystrophy. Increased prevalence of OHT/SG was shown with PK versus DSEK; possible mechanisms include mechanical closure of Schlemms canal by running suture and prolonged steroid use.

AB - OBJECTIVES:: The prevalence of primary open-angle glaucoma (POAG) in patients with corneal endothelial dystrophy has not been previously studied. Prevalence of POAG in patients with endothelial dystrophy was compared with that in the general population to determine the presence of a relationship between the diseases. DESIGN:: Retrospective case-control study. METHODS:: A study of the prevalence of POAG in 430 eyes of 215 patients with endothelial dystrophy was conducted. Patients followed for less than 6 months were excluded. Relative risk of POAG was calculated using age-and race-matched control data from the Baltimore Eye Survey and the Los Angeles Latino Eye Survey for comparison. Ocular hypertension (OHT) and secondary glaucoma (SG) rates after penetrating keratoplasty (PK) and Descemet stripping endothelial keratoplasty (DSEK) were separately analyzed. RESULTS:: Relative risk of POAG in white, African American, and Hispanic patients with endothelial dystrophy was 0.94, 2.59, and 3.7, respectively (P = 0.89, 95% confidence interval [CI], -0.028 to 0.0289; P = 0.13; 95% CI, 0.011-0.274; P = 0.055; 95% CI, 0.0423-0.356). Relative risk of SG and combined OHT/SG in PK versus DSEK was 4.15 and 1.95 (P < 0.001; 95% CI, 0.0654-0.322; P = 0.005; 95% CI, 0.116-0.332), respectively. No differences in OHT/SG rates were found comparing PK-triple with PK, DSEK-triple with DSEK, and repeat with primary PK or DSEK (P = 0.98; P = 0.62; P = 0.95; P = 0.87), respectively. CONCLUSIONS:: No increased risk of POAG was found in patients with endothelial dystrophy. Increased prevalence of OHT/SG was shown with PK versus DSEK; possible mechanisms include mechanical closure of Schlemms canal by running suture and prolonged steroid use.

KW - Corneal endothelial dystrophy

KW - Fuchs' dystrophy

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KW - Primary open-angle glaucoma

KW - Secondary glaucoma

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