Glioblastoma: Exosome and microRNA as novel diagnosis biomarkers

L. Saadatpour, E. Fadaee, S. Fadaei, R. Nassiri Mansour, M. Mohammadi, S. M. Mousavi, M. Goodarzi, J. Verdi, H. Mirzaei

Research output: Contribution to journalReview article

87 Scopus citations

Abstract

Glioblastoma (GBM) is known as a tumor type, which arises from astrocytes. Several studies indicated that GBM tumor cells are malignant. This is because of the fact that they consist of different cell types, which are reproducing very quickly and are also supported by a large network of blood vessels. The correct identification of various stages of GBM could help to better treat the patients with this disease. Therefore, new biomarkers such as exosomes and microRNAs (miRNAs) may help us to learn more about GBM and they may also lead to a more effective treatment for patients with GBM. Exosomes have emerged as biological vehicles, which can perform various tasks in carcinogenesis pathways such as PI3K/AKT, SOX2, PTEN, ERK, and STAT3. The miRNAs are known as small noncoding RNAs that are involved in several GBM pathogenic events. These molecules have key roles in various biological processes such as angiogenesis, metastasis and tumor growth. In this study, we highlighted various exosomes and miRNAs that could be used for diagnosis and/or prognosis biomarkers in patients with GBM.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalCancer Gene Therapy
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2016

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ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

Cite this

Saadatpour, L., Fadaee, E., Fadaei, S., Nassiri Mansour, R., Mohammadi, M., Mousavi, S. M., Goodarzi, M., Verdi, J., & Mirzaei, H. (2016). Glioblastoma: Exosome and microRNA as novel diagnosis biomarkers. Cancer Gene Therapy, 23(12), 415-418. https://doi.org/10.1038/cgt.2016.48