Glioblastoma multiforme

Jennifer L. Shah, Gordon H. Li, Scott G. Soltys

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. Despite the standard of care of radiotherapy with concurrent and adjuvant temozolomide chemotherapy, prognosis is poor, with a median survival of approximately 16 months. Tumor recurrence within the high dose irradiation field occurs in up to 80% of patients, suggesting a role for further radiation dose intensification. One means to intensify dose is through radiotherapy hypofractionation with large doses per fraction or with radiosurgery. This chapter will review the past results of hypofractionated radiotherapy and stereotactic radiosurgery for patients with GBM, both at initial diagnosis and after recurrence. The CyberKnife is uniquely capable of delivering radiotherapy and radiosurgery at all phases of the treatment course of GBM.

Original languageEnglish (US)
Title of host publicationCyberKnife Stereotactic Radiosurgery
Subtitle of host publicationBrain
PublisherNova Science Publishers, Inc.
Pages85-98
Number of pages14
Volume1
ISBN (Electronic)9781631177736
ISBN (Print)9781631177644
Publication statusPublished - Jan 1 2014

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shah, J. L., Li, G. H., & Soltys, S. G. (2014). Glioblastoma multiforme. In CyberKnife Stereotactic Radiosurgery: Brain (Vol. 1, pp. 85-98). Nova Science Publishers, Inc..