Abstract
Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 158-164 |
| Number of pages | 7 |
| Journal | BMB Reports |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2011 |
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Keywords
- Glioblastoma
- Glioma
- Glioma stem cells
- Mouse models of glioma
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
Cite this
Glioblastoma multiforme : A perspective on recent findings in human cancer and mouse models. / Lim, Sang Kyun; Llaguno, Sheila R Alcantara; McKay, Renée M.; Parada, Luis F.
In: BMB Reports, Vol. 44, No. 3, 03.2011, p. 158-164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glioblastoma multiforme
T2 - A perspective on recent findings in human cancer and mouse models
AU - Lim, Sang Kyun
AU - Llaguno, Sheila R Alcantara
AU - McKay, Renée M.
AU - Parada, Luis F.
PY - 2011/3
Y1 - 2011/3
N2 - Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed.
AB - Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed.
KW - Glioblastoma
KW - Glioma
KW - Glioma stem cells
KW - Mouse models of glioma
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UR - http://www.scopus.com/inward/citedby.url?scp=79953220806&partnerID=8YFLogxK
U2 - 10.5483/BMBRep.2011.44.3.158
DO - 10.5483/BMBRep.2011.44.3.158
M3 - Article
VL - 44
SP - 158
EP - 164
JO - BMB Reports
JF - BMB Reports
SN - 1976-6696
IS - 3
ER -