Global diversity in the TAS2R38 bitter taste receptor: Revisiting a classic evolutionary PROPosal

Davide S. Risso, Massimo Mezzavilla, Luca Pagani, Antonietta Robino, Gabriella Morini, Sergio Tofanelli, Maura Carrai, Daniele Campa, Roberto Barale, Fabio Caradonna, Paolo Gasparini, Donata Luiselli, Stephen Wooding, Dennis Drayna

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selection and demography on contemporary patterns of variation at this locus. We found signs of an ancient balancing selection acting on this gene but no post Out-Of-Africa departures from neutrality, implying that the current observed patterns of variation can be predominantly explained by demographic, rather than selective events. In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes.

Original languageEnglish (US)
Article number25506
JournalScientific Reports
Volume6
DOIs
StatePublished - May 3 2016

Fingerprint

Haplotypes
Genetic Selection
Demography
Genes
Phenylthiourea
Propylthiouracil
Aptitude
Linkage Disequilibrium
Population Genetics
Databases
Pressure
Population

ASJC Scopus subject areas

  • General

Cite this

Risso, D. S., Mezzavilla, M., Pagani, L., Robino, A., Morini, G., Tofanelli, S., ... Drayna, D. (2016). Global diversity in the TAS2R38 bitter taste receptor: Revisiting a classic evolutionary PROPosal. Scientific Reports, 6, [25506]. https://doi.org/10.1038/srep25506

Global diversity in the TAS2R38 bitter taste receptor : Revisiting a classic evolutionary PROPosal. / Risso, Davide S.; Mezzavilla, Massimo; Pagani, Luca; Robino, Antonietta; Morini, Gabriella; Tofanelli, Sergio; Carrai, Maura; Campa, Daniele; Barale, Roberto; Caradonna, Fabio; Gasparini, Paolo; Luiselli, Donata; Wooding, Stephen; Drayna, Dennis.

In: Scientific Reports, Vol. 6, 25506, 03.05.2016.

Research output: Contribution to journalArticle

Risso, DS, Mezzavilla, M, Pagani, L, Robino, A, Morini, G, Tofanelli, S, Carrai, M, Campa, D, Barale, R, Caradonna, F, Gasparini, P, Luiselli, D, Wooding, S & Drayna, D 2016, 'Global diversity in the TAS2R38 bitter taste receptor: Revisiting a classic evolutionary PROPosal', Scientific Reports, vol. 6, 25506. https://doi.org/10.1038/srep25506
Risso, Davide S. ; Mezzavilla, Massimo ; Pagani, Luca ; Robino, Antonietta ; Morini, Gabriella ; Tofanelli, Sergio ; Carrai, Maura ; Campa, Daniele ; Barale, Roberto ; Caradonna, Fabio ; Gasparini, Paolo ; Luiselli, Donata ; Wooding, Stephen ; Drayna, Dennis. / Global diversity in the TAS2R38 bitter taste receptor : Revisiting a classic evolutionary PROPosal. In: Scientific Reports. 2016 ; Vol. 6.
@article{076036658a664c70af020a63577692ff,
title = "Global diversity in the TAS2R38 bitter taste receptor: Revisiting a classic evolutionary PROPosal",
abstract = "The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selection and demography on contemporary patterns of variation at this locus. We found signs of an ancient balancing selection acting on this gene but no post Out-Of-Africa departures from neutrality, implying that the current observed patterns of variation can be predominantly explained by demographic, rather than selective events. In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes.",
author = "Risso, {Davide S.} and Massimo Mezzavilla and Luca Pagani and Antonietta Robino and Gabriella Morini and Sergio Tofanelli and Maura Carrai and Daniele Campa and Roberto Barale and Fabio Caradonna and Paolo Gasparini and Donata Luiselli and Stephen Wooding and Dennis Drayna",
year = "2016",
month = "5",
day = "3",
doi = "10.1038/srep25506",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Global diversity in the TAS2R38 bitter taste receptor

T2 - Revisiting a classic evolutionary PROPosal

AU - Risso, Davide S.

AU - Mezzavilla, Massimo

AU - Pagani, Luca

AU - Robino, Antonietta

AU - Morini, Gabriella

AU - Tofanelli, Sergio

AU - Carrai, Maura

AU - Campa, Daniele

AU - Barale, Roberto

AU - Caradonna, Fabio

AU - Gasparini, Paolo

AU - Luiselli, Donata

AU - Wooding, Stephen

AU - Drayna, Dennis

PY - 2016/5/3

Y1 - 2016/5/3

N2 - The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selection and demography on contemporary patterns of variation at this locus. We found signs of an ancient balancing selection acting on this gene but no post Out-Of-Africa departures from neutrality, implying that the current observed patterns of variation can be predominantly explained by demographic, rather than selective events. In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes.

AB - The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selection and demography on contemporary patterns of variation at this locus. We found signs of an ancient balancing selection acting on this gene but no post Out-Of-Africa departures from neutrality, implying that the current observed patterns of variation can be predominantly explained by demographic, rather than selective events. In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes.

UR - http://www.scopus.com/inward/record.url?scp=84966356381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966356381&partnerID=8YFLogxK

U2 - 10.1038/srep25506

DO - 10.1038/srep25506

M3 - Article

C2 - 27138342

AN - SCOPUS:84966356381

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 25506

ER -