TY - JOUR
T1 - Global gray matter morphometry differences between children with reading disability, ADHD, and comorbid reading disability/ADHD
AU - Jagger-Rickels, Audreyana C.
AU - Kibby, Michelle Y.
AU - Constance, Jordan M.
N1 - Funding Information:
NIH/NICHD funded data collection for this study (R03 HD048752, R15 HD065627). The opinions expressed in this article may not reflect the views of NIH/NICHD.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/10
Y1 - 2018/10
N2 - Extensive, yet disparate, research exists elucidating structural anomalies in individuals with Reading Disability (RD) or ADHD. Despite ADHD and RD being highly comorbid, minimal research has attempted to determine shared patterns of morphometry between these disorders. In addition, there is no published research examining the morphometry of comorbid RD and ADHD (RD/ADHD). Hence, we conducted voxel-based morphometry on the MRI scans of 106 children, ages 8–12 years, with RD, ADHD, or RD/ADHD, and typically developing controls. We found right caudate and superior frontal regions in both RD and ADHD, along with areas specific to RD and to ADHD that are consistent with current theories on these disorders. Perhaps most importantly, we found a potential neurobiological substrate for RD/ADHD. Further, our findings illustrate both shared and specific contributors to RD/ADHD, supporting two current theories on the comorbidity of RD and ADHD, thereby facilitating future work on potential etiologies of RD/ADHD.
AB - Extensive, yet disparate, research exists elucidating structural anomalies in individuals with Reading Disability (RD) or ADHD. Despite ADHD and RD being highly comorbid, minimal research has attempted to determine shared patterns of morphometry between these disorders. In addition, there is no published research examining the morphometry of comorbid RD and ADHD (RD/ADHD). Hence, we conducted voxel-based morphometry on the MRI scans of 106 children, ages 8–12 years, with RD, ADHD, or RD/ADHD, and typically developing controls. We found right caudate and superior frontal regions in both RD and ADHD, along with areas specific to RD and to ADHD that are consistent with current theories on these disorders. Perhaps most importantly, we found a potential neurobiological substrate for RD/ADHD. Further, our findings illustrate both shared and specific contributors to RD/ADHD, supporting two current theories on the comorbidity of RD and ADHD, thereby facilitating future work on potential etiologies of RD/ADHD.
KW - ADHD
KW - Frontal lobes
KW - Morphometry
KW - Occipital lobes
KW - Reading disability
KW - Reading disability/ADHD
KW - Striatum
KW - Structural neuroimaging
KW - Thalamus
KW - VBM
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U2 - 10.1016/j.bandl.2018.08.004
DO - 10.1016/j.bandl.2018.08.004
M3 - Article
C2 - 30189332
AN - SCOPUS:85052611219
SN - 0093-934X
VL - 185
SP - 54
EP - 66
JO - Brain and Language
JF - Brain and Language
ER -