Global left ventricular contractility in three models of hypertrophy evaluated with Emax

David Alyono, W. Steves Ring, Arthur J. Crumbley, Joseph R. Schneider, Melody J. O'Connor, Deborah Parrish, Robert J. Bache, Robert W. Anderson

Research output: Contribution to journalArticle

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Abstract

Using the load independent contractility index, end-systolic pressure-volume ratio (Emax), contractility of the hypertrophied left ventricle (LV) from three different models was evaluated in conscious, resting dogs. The experimental animals included 12 dogs with perinephritic hypertension (HYP) (aortic diastolic pressure 130 ± 5 mm Hg), 12 dogs who underwent aortic banding (AOB) at 6 to 8 weeks of age (resting aortic gradient 110 ± 15 mm Hg), and 12 dogs with chronic fluid overload from aortocaval fistula (ACF). These were compared with 12 normal dogs (CTL). LV dimension and pressure were measured with ultrasonic tranducers and micromanometers. All three models resulted in hypertrophy with significant (P < 0.01) increase in LV weight-to-body weight ratio (6.3 ± 0.4, 8.4 ± 0.5, 6.3 ± 0.4, respectively, vs 4.4 ± 0.1 g/kg). Cardiac output (6908 ± 740 vs 2424 ± 276 ml/min) and end-diastolic volume (118 ± 11 vs 50 ± 4 ml) were significantly (P < 0.01) increased in AOB (18 ± 1 vs 9 ± 2 mm Hg). dp/dtmax was not significantly different among all groups. Emax (CTL = 5.3 ± 0.4 mm Hg/ml) was not significantly changed in HYP (9.5 ± 2.1) but was significantly (P < 0.01) increased in AOB (14.1 ± 2.6), and significantly (P < 0.01) depressed in ACF (2.4 ± .03). Thus, LV hypertrophy from systemic hypertension (HYP) or proximal aortic hypertension (AOB) is, at least initially, associated with preservation of contractility and normal hemodynamic performance. However, LV contractility of hypertrophied heart from chronic fluid overload (ACF) was depressed, and the normal (or increased) hemodynamic performance (dp/dtmax, peak left ventricular pressure, cardiac output) appeared to be maintained by utilizing Starling preload reserves.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalJournal of Surgical Research
Volume37
Issue number1
DOIs
StatePublished - 1984

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Hypertrophy
Heart Ventricles
Dogs
Hypertension
Fistula
Cardiac Output
Hemodynamics
Blood Pressure
Myocardial Contraction
Starlings
Ventricular Pressure
Ultrasonics
Arterial Pressure
Body Weight
Pressure
Weights and Measures

ASJC Scopus subject areas

  • Surgery

Cite this

Alyono, D., Steves Ring, W., Crumbley, A. J., Schneider, J. R., O'Connor, M. J., Parrish, D., ... Anderson, R. W. (1984). Global left ventricular contractility in three models of hypertrophy evaluated with Emax Journal of Surgical Research, 37(1), 48-54. https://doi.org/10.1016/0022-4804(84)90160-4

Global left ventricular contractility in three models of hypertrophy evaluated with Emax . / Alyono, David; Steves Ring, W.; Crumbley, Arthur J.; Schneider, Joseph R.; O'Connor, Melody J.; Parrish, Deborah; Bache, Robert J.; Anderson, Robert W.

In: Journal of Surgical Research, Vol. 37, No. 1, 1984, p. 48-54.

Research output: Contribution to journalArticle

Alyono, D, Steves Ring, W, Crumbley, AJ, Schneider, JR, O'Connor, MJ, Parrish, D, Bache, RJ & Anderson, RW 1984, 'Global left ventricular contractility in three models of hypertrophy evaluated with Emax ', Journal of Surgical Research, vol. 37, no. 1, pp. 48-54. https://doi.org/10.1016/0022-4804(84)90160-4
Alyono, David ; Steves Ring, W. ; Crumbley, Arthur J. ; Schneider, Joseph R. ; O'Connor, Melody J. ; Parrish, Deborah ; Bache, Robert J. ; Anderson, Robert W. / Global left ventricular contractility in three models of hypertrophy evaluated with Emax In: Journal of Surgical Research. 1984 ; Vol. 37, No. 1. pp. 48-54.
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