Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019

Emma Nichols; Foad Abd-Allah; Amir Abdoli; Akine Eshete Abosetugn; Woldu Aberhe Abrha; Ahmed Abualhasan; Eman Abu-Gharbieh; Rufus Olusola Akinyemi; Fares Alahdab; Fahad Mashhour Alanezi; Vahid Alipour; Iman Ansari; Jalal Arabloo; Amir Ashraf-Ganjouei; Abolfazl Avan; Getinet Ayano; Zaheer Ud Din Babar; Atif Amin Baig; Maciej Banach; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Bernhard T. Baune; Akshaya Srikanth Bhagavathula; Krittika Bhattacharyya; Ali Bijani; Antonio Biondi; Tsegaye Adane Birhan; Atanu Biswas; Srinivasa Rao Bolla; Archith Boloor; Carol Brayne; Hermann Brenner; Katrin Burkart; Richard A. Burns; Sharath Burugina Nagaraja; Felix Carvalho; Luis F.S. Castro-De-araujo; Ferrán Catalá-López; Ester Cerin; Achille Cernigliaro; Nicolas Cherbuin; Jee Young Jasmine Choi; Dinh Toi Chu; Baye Dagnew; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Abdel Douiri; Bruce B. Duncan; David Edvardsson; Shaimaa I. El-Jaafary; Khalil Eskandari; Sharareh Eskandarieh; Valery L. Feigin; Seyed Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Florian Fischer; Shilpa Gaidhane; Kidane Zereabruk Gebregzabiher; Ahmad Ghashghaee; Asadollah Gholamian; Elena V. Gnedovskaya; Mahaveer Golechha; Rajeev Gupta; Vladimir Hachinski; Samer Hamidi; Graeme J. Hankey; Josep Maria Haro; Amr Hassan; Simon I. Hay; Golnaz Heidari; Reza Heidari-Soureshjani; Mowafa Househ; Rabia Hussain; Bing Fang Hwang; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Hiroyasu Iso; Masao Iwagami; Ravi Prakash Jha; Rizwan Kalani; Himal Kandel; André Karch; Ayele Semachew Kasa; Andre Pascal Kengne; Young Eun Kim; Yun Jin Kim; Sezer Kisa; Adnan Kisa; Mika Kivimäki; Hamidreza Komaki; Aikoyanagi; Walter A. Kukull; G. Anil Kumar; Manasi Kumar; Iván Landires; Matilde Leonardi; Stephen S. Lim; Xuefeng Liu; Giancarlo Logroscino; Alan D. Lopez; Stefan Lorkowski; Clement T. Loy; Hawraz Ibrahim M. Amin; Navid Manafi; Narayana Manjunatha; Man Mohan Mehndiratta; Ritesh G. Menezes; Atte Meretoja; Alexander Merkin; Workua Mekonnen Metekiya; Awoke Temesgen Misganaw; Bahram Mohajer; Norlinah Mohamed Ibrahim; Yousef Mohammad; Archisman Mohapatra; Farnam Mohebi; Ali H. Mokdad; Stefania Mondello; Tilahun Belete Mossie; Anwar Mulugeta; Gabriele Nagel; Muhammad Naveed; Vinod C. Nayak; Sandhya Neupane Kandel; Son Hoang Nguyen; Huong Lan Thi Nguyen; Virginia Nuñez-Samudio; Felix Akpojene Ogbo; Andrew T. Olagunju; Hans Orru; Sergej M. Ostojic; Samuel M. Ostroff; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; Mona Pathak; Hamidreza Pazoki Toroudi; Carrie B. Peterson; Hai Quang Pham; Michael R. Phillips; Michael A. Piradov; Faheem Hyder Pottoo; Sergio I. Prada; Dimas Ria Angga Pribadi; Amir Radfar; Alberto Raggi; Fakher Rahim; Pradhum Ram; Juwel Rana; Vahid Rashedi; Salman Rawaf; David Laith Rawaf; Nickolas Reinig; Nima Rezaei; Stephen R. Robinson; Michele Romoli; Perminder S. Sachdev; Ramesh Sahathevan; Amirhossein Sahebkar; Mohammad Ali Sahraian; Davide Sattin; Mete Saylan; Mehdi Sayyah; Silvia Schiavolin; Maria Inês Schmidt; Izza Shahid; Masood Ali Shaikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Tariq Jamal Siddiqi; João Pedro Silva; Jasvinder A. Singh; Amin Soheili; Emma Elizabeth Spurlock; Cassandra E.I. Szoeke; Rafael Tabarés-Seisdedos; Biruk Wogayehu Taddele; Bhaskar Thakur; Akhil Soman Thekke Purakkal; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Ravensara S. Travillian; Manjari Tripathi; Gebiyaw Wudie Tsegaye; Muhammad Shariq Usman; Marco Vacante; Diana Zuleika Velazquez; Narayanaswamy Venketasubramanian; Simone Vidale; Vasily Vlassov; Yuan Pang Wang; Jingkai Wei; Jordan Weiss; Abrha Hailay Weldemariam; Anders Wimo; Chenkai Wu; Ali Yadollahpour; Kazumasa Yamagishi; Yordanos Gizachew Yeshitila; Naohiro Yonemoto; Siddhesh Zadey; Zhi Jiang Zhang; Christopher J.L. Murray; Theo Vos

doi:10.1002/trc2.12200

Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019

Emma Nichols, Foad Abd-Allah, Amir Abdoli, Akine Eshete Abosetugn, Woldu Aberhe Abrha, Ahmed Abualhasan, Eman Abu-Gharbieh, Rufus Olusola Akinyemi, Fares Alahdab, Fahad Mashhour Alanezi, Vahid Alipour, Iman Ansari, Jalal Arabloo, Amir Ashraf-Ganjouei, Abolfazl Avan, Getinet Ayano, Zaheer Ud Din Babar, Atif Amin Baig, Maciej Banach, Miguel A. BarbozaSuzanne Lyn Barker-Collo, Bernhard T. Baune, Akshaya Srikanth Bhagavathula, Krittika Bhattacharyya, Ali Bijani, Antonio Biondi, Tsegaye Adane Birhan, Atanu Biswas, Srinivasa Rao Bolla, Archith Boloor, Carol Brayne, Hermann Brenner, Katrin Burkart, Richard A. Burns, Sharath Burugina Nagaraja, Felix Carvalho, Luis F.S. Castro-De-araujo, Ferrán Catalá-López, Ester Cerin, Achille Cernigliaro, Nicolas Cherbuin, Jee Young Jasmine Choi, Dinh Toi Chu, Baye Dagnew, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Daniel Diaz, Zahra Sadat Dibaji Forooshani, Abdel Douiri, Bruce B. Duncan, David Edvardsson, Shaimaa I. El-Jaafary, Khalil Eskandari, Sharareh Eskandarieh, Valery L. Feigin, Seyed Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Irina Filip, Florian Fischer, Shilpa Gaidhane, Kidane Zereabruk Gebregzabiher, Ahmad Ghashghaee, Asadollah Gholamian, Elena V. Gnedovskaya, Mahaveer Golechha, Rajeev Gupta, Vladimir Hachinski, Samer Hamidi, Graeme J. Hankey, Josep Maria Haro, Amr Hassan, Simon I. Hay, Golnaz Heidari, Reza Heidari-Soureshjani, Mowafa Househ, Rabia Hussain, Bing Fang Hwang, Irena M. Ilic, Milena D. Ilic, Seyed Sina Naghibi Irvani, Hiroyasu Iso, Masao Iwagami, Ravi Prakash Jha, Rizwan Kalani, Himal Kandel, André Karch, Ayele Semachew Kasa, Andre Pascal Kengne, Young Eun Kim, Yun Jin Kim, Sezer Kisa, Adnan Kisa, Mika Kivimäki, Hamidreza Komaki, Aikoyanagi, Walter A. Kukull, G. Anil Kumar, Manasi Kumar, Iván Landires, Matilde Leonardi, Stephen S. Lim, Xuefeng Liu, Giancarlo Logroscino, Alan D. Lopez, Stefan Lorkowski, Clement T. Loy, Hawraz Ibrahim M. Amin, Navid Manafi, Narayana Manjunatha, Man Mohan Mehndiratta, Ritesh G. Menezes, Atte Meretoja, Alexander Merkin, Workua Mekonnen Metekiya, Awoke Temesgen Misganaw, Bahram Mohajer, Norlinah Mohamed Ibrahim, Yousef Mohammad, Archisman Mohapatra, Farnam Mohebi, Ali H. Mokdad, Stefania Mondello, Tilahun Belete Mossie, Anwar Mulugeta, Gabriele Nagel, Muhammad Naveed, Vinod C. Nayak, Sandhya Neupane Kandel, Son Hoang Nguyen, Huong Lan Thi Nguyen, Virginia Nuñez-Samudio, Felix Akpojene Ogbo, Andrew T. Olagunju, Hans Orru, Sergej M. Ostojic, Samuel M. Ostroff, Nikita Otstavnov, Stanislav S. Otstavnov, Mayowa O. Owolabi, Mona Pathak, Hamidreza Pazoki Toroudi, Carrie B. Peterson, Hai Quang Pham, Michael R. Phillips, Michael A. Piradov, Faheem Hyder Pottoo, Sergio I. Prada, Dimas Ria Angga Pribadi, Amir Radfar, Alberto Raggi, Fakher Rahim, Pradhum Ram, Juwel Rana, Vahid Rashedi, Salman Rawaf, David Laith Rawaf, Nickolas Reinig, Nima Rezaei, Stephen R. Robinson, Michele Romoli, Perminder S. Sachdev, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Davide Sattin, Mete Saylan, Mehdi Sayyah, Silvia Schiavolin, Maria Inês Schmidt, Izza Shahid, Masood Ali Shaikh, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Tariq Jamal Siddiqi, João Pedro Silva, Jasvinder A. Singh, Amin Soheili, Emma Elizabeth Spurlock, Cassandra E.I. Szoeke, Rafael Tabarés-Seisdedos, Biruk Wogayehu Taddele, Bhaskar Thakur, Akhil Soman Thekke Purakkal, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Ravensara S. Travillian, Manjari Tripathi, Gebiyaw Wudie Tsegaye, Muhammad Shariq Usman, Marco Vacante, Diana Zuleika Velazquez, Narayanaswamy Venketasubramanian, Simone Vidale, Vasily Vlassov, Yuan Pang Wang, Jingkai Wei, Jordan Weiss, Abrha Hailay Weldemariam, Anders Wimo, Chenkai Wu, Ali Yadollahpour, Kazumasa Yamagishi, Yordanos Gizachew Yeshitila, Naohiro Yonemoto, Siddhesh Zadey, Zhi Jiang Zhang, Christopher J.L. Murray, Theo Vos

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

Original language	English (US)
Article number	e12200
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	7
Issue number	1
DOIs	https://doi.org/10.1002/trc2.12200
State	Published - 2021
Externally published	Yes

Keywords

Burden of disease
Dementia
Global health
Mortality

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

Access to Document

10.1002/trc2.12200

Cite this

Nichols, E., Abd-Allah, F., Abdoli, A., Abosetugn, A. E., Abrha, W. A., Abualhasan, A., Abu-Gharbieh, E., Akinyemi, R. O., Alahdab, F., Alanezi, F. M., Alipour, V., Ansari, I., Arabloo, J., Ashraf-Ganjouei, A., Avan, A., Ayano, G., Babar, Z. U. D., Baig, A. A., Banach, M., ... Vos, T. (2021). Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 7(1), Article e12200. https://doi.org/10.1002/trc2.12200

Nichols, E, Abd-Allah, F, Abdoli, A, Abosetugn, AE, Abrha, WA, Abualhasan, A, Abu-Gharbieh, E, Akinyemi, RO, Alahdab, F, Alanezi, FM, Alipour, V, Ansari, I, Arabloo, J, Ashraf-Ganjouei, A, Avan, A, Ayano, G, Babar, ZUD, Baig, AA, Banach, M, Barboza, MA, Barker-Collo, SL, Baune, BT, Srikanth Bhagavathula, A, Bhattacharyya, K, Bijani, A, Biondi, A, Birhan, TA, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Nagaraja, SB, Carvalho, F, Castro-De-araujo, LFS, Catalá-López, F, Cerin, E, Cernigliaro, A, Cherbuin, N, Jasmine Choi, JY, Chu, DT, Dagnew, B, Dai, X, Dandona, L, Dandona, R, Diaz, D, Dibaji Forooshani, ZS, Douiri, A, Duncan, BB, Edvardsson, D, El-Jaafary, SI, Eskandari, K, Eskandarieh, S, Feigin, VL, Fereshtehnejad, SM, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Gaidhane, S, Gebregzabiher, KZ, Ghashghaee, A, Gholamian, A, Gnedovskaya, EV, Golechha, M, Gupta, R, Hachinski, V, Hamidi, S, Hankey, GJ, Haro, JM, Hassan, A, Hay, SI, Heidari, G, Heidari-Soureshjani, R, Househ, M, Hussain, R, Hwang, BF, Ilic, IM, Ilic, MD, Naghibi Irvani, SS, Iso, H, Iwagami, M, Jha, RP, Kalani, R, Kandel, H, Karch, A, Kasa, AS, Kengne, AP, Kim, YE, Kim, YJ, Kisa, S, Kisa, A, Kivimäki, M, Komaki, H, Aikoyanagi, Kukull, WA, Kumar, GA, Kumar, M, Landires, I, Leonardi, M, Lim, SS, Liu, X, Logroscino, G, Lopez, AD, Lorkowski, S, Loy, CT, Amin, HIM, Manafi, N, Manjunatha, N, Mehndiratta, MM, Menezes, RG, Meretoja, A, Merkin, A, Metekiya, WM, Misganaw, AT, Mohajer, B, Ibrahim, NM, Mohammad, Y, Mohapatra, A, Mohebi, F, Mokdad, AH, Mondello, S, Mossie, TB, Mulugeta, A, Nagel, G, Naveed, M, Nayak, VC, Kandel, SN, Nguyen, SH, Nguyen, HLT, Nuñez-Samudio, V, Ogbo, FA, Olagunju, AT, Orru, H, Ostojic, SM, Ostroff, SM, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Pathak, M, Toroudi, HP, Peterson, CB, Pham, HQ, Phillips, MR, Piradov, MA, Pottoo, FH, Prada, SI, Angga Pribadi, DR, Radfar, A, Raggi, A, Rahim, F, Ram, P, Rana, J, Rashedi, V, Rawaf, S, Rawaf, DL, Reinig, N, Rezaei, N, Robinson, SR, Romoli, M, Sachdev, PS, Sahathevan, R, Sahebkar, A, Sahraian, MA, Sattin, D, Saylan, M, Sayyah, M, Schiavolin, S, Schmidt, MI, Shahid, I, Shaikh, MA, Shigematsu, M, Shin, JI, Shiri, R, Siddiqi, TJ, Silva, JP, Singh, JA, Soheili, A, Spurlock, EE, Szoeke, CEI, Tabarés-Seisdedos, R, Taddele, BW, Thakur, B, Thekke Purakkal, AS, Tovani-Palone, MR, Tran, BX, Travillian, RS, Tripathi, M, Tsegaye, GW, Usman, MS, Vacante, M, Velazquez, DZ, Venketasubramanian, N, Vidale, S, Vlassov, V, Wang, YP, Wei, J, Weiss, J, Weldemariam, AH, Wimo, A, Wu, C, Yadollahpour, A, Yamagishi, K, Yeshitila, YG, Yonemoto, N, Zadey, S, Zhang, ZJ, Murray, CJL & Vos, T 2021, 'Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 7, no. 1, e12200. https://doi.org/10.1002/trc2.12200

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title = "Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019",

abstract = "Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.",

keywords = "Burden of disease, Dementia, Global health, Mortality",

author = "Emma Nichols and Foad Abd-Allah and Amir Abdoli and Abosetugn, {Akine Eshete} and Abrha, {Woldu Aberhe} and Ahmed Abualhasan and Eman Abu-Gharbieh and Akinyemi, {Rufus Olusola} and Fares Alahdab and Alanezi, {Fahad Mashhour} and Vahid Alipour and Iman Ansari and Jalal Arabloo and Amir Ashraf-Ganjouei and Abolfazl Avan and Getinet Ayano and Babar, {Zaheer Ud Din} and Baig, {Atif Amin} and Maciej Banach and Barboza, {Miguel A.} and Barker-Collo, {Suzanne Lyn} and Baune, {Bernhard T.} and {Srikanth Bhagavathula}, Akshaya and Krittika Bhattacharyya and Ali Bijani and Antonio Biondi and Birhan, {Tsegaye Adane} and Atanu Biswas and Bolla, {Srinivasa Rao} and Archith Boloor and Carol Brayne and Hermann Brenner and Katrin Burkart and Burns, {Richard A.} and Nagaraja, {Sharath Burugina} and Felix Carvalho and Castro-De-araujo, {Luis F.S.} and Ferr{\'a}n Catal{\'a}-L{\'o}pez and Ester Cerin and Achille Cernigliaro and Nicolas Cherbuin and {Jasmine Choi}, {Jee Young} and Chu, {Dinh Toi} and Baye Dagnew and Xiaochen Dai and Lalit Dandona and Rakhi Dandona and Daniel Diaz and {Dibaji Forooshani}, {Zahra Sadat} and Abdel Douiri and Duncan, {Bruce B.} and David Edvardsson and El-Jaafary, {Shaimaa I.} and Khalil Eskandari and Sharareh Eskandarieh and Feigin, {Valery L.} and Fereshtehnejad, {Seyed Mohammad} and Eduarda Fernandes and Pietro Ferrara and Irina Filip and Florian Fischer and Shilpa Gaidhane and Gebregzabiher, {Kidane Zereabruk} and Ahmad Ghashghaee and Asadollah Gholamian and Gnedovskaya, {Elena V.} and Mahaveer Golechha and Rajeev Gupta and Vladimir Hachinski and Samer Hamidi and Hankey, {Graeme J.} and Haro, {Josep Maria} and Amr Hassan and Hay, {Simon I.} and Golnaz Heidari and Reza Heidari-Soureshjani and Mowafa Househ and Rabia Hussain and Hwang, {Bing Fang} and Ilic, {Irena M.} and Ilic, {Milena D.} and {Naghibi Irvani}, {Seyed Sina} and Hiroyasu Iso and Masao Iwagami and Jha, {Ravi Prakash} and Rizwan Kalani and Himal Kandel and Andr{\'e} Karch and Kasa, {Ayele Semachew} and Kengne, {Andre Pascal} and Kim, {Young Eun} and Kim, {Yun Jin} and Sezer Kisa and Adnan Kisa and Mika Kivim{\"a}ki and Hamidreza Komaki and Aikoyanagi and Kukull, {Walter A.} and Kumar, {G. Anil} and Manasi Kumar and Iv{\'a}n Landires and Matilde Leonardi and Lim, {Stephen S.} and Xuefeng Liu and Giancarlo Logroscino and Lopez, {Alan D.} and Stefan Lorkowski and Loy, {Clement T.} and Amin, {Hawraz Ibrahim M.} and Navid Manafi and Narayana Manjunatha and Mehndiratta, {Man Mohan} and Menezes, {Ritesh G.} and Atte Meretoja and Alexander Merkin and Metekiya, {Workua Mekonnen} and Misganaw, {Awoke Temesgen} and Bahram Mohajer and Ibrahim, {Norlinah Mohamed} and Yousef Mohammad and Archisman Mohapatra and Farnam Mohebi and Mokdad, {Ali H.} and Stefania Mondello and Mossie, {Tilahun Belete} and Anwar Mulugeta and Gabriele Nagel and Muhammad Naveed and Nayak, {Vinod C.} and Kandel, {Sandhya Neupane} and Nguyen, {Son Hoang} and Nguyen, {Huong Lan Thi} and Virginia Nu{\~n}ez-Samudio and Ogbo, {Felix Akpojene} and Olagunju, {Andrew T.} and Hans Orru and Ostojic, {Sergej M.} and Ostroff, {Samuel M.} and Nikita Otstavnov and Otstavnov, {Stanislav S.} and Owolabi, {Mayowa O.} and Mona Pathak and Toroudi, {Hamidreza Pazoki} and Peterson, {Carrie B.} and Pham, {Hai Quang} and Phillips, {Michael R.} and Piradov, {Michael A.} and Pottoo, {Faheem Hyder} and Prada, {Sergio I.} and {Angga Pribadi}, {Dimas Ria} and Amir Radfar and Alberto Raggi and Fakher Rahim and Pradhum Ram and Juwel Rana and Vahid Rashedi and Salman Rawaf and Rawaf, {David Laith} and Nickolas Reinig and Nima Rezaei and Robinson, {Stephen R.} and Michele Romoli and Sachdev, {Perminder S.} and Ramesh Sahathevan and Amirhossein Sahebkar and Sahraian, {Mohammad Ali} and Davide Sattin and Mete Saylan and Mehdi Sayyah and Silvia Schiavolin and Schmidt, {Maria In{\^e}s} and Izza Shahid and Shaikh, {Masood Ali} and Mika Shigematsu and Shin, {Jae Il} and Rahman Shiri and Siddiqi, {Tariq Jamal} and Silva, {Jo{\~a}o Pedro} and Singh, {Jasvinder A.} and Amin Soheili and Spurlock, {Emma Elizabeth} and Szoeke, {Cassandra E.I.} and Rafael Tabar{\'e}s-Seisdedos and Taddele, {Biruk Wogayehu} and Bhaskar Thakur and {Thekke Purakkal}, {Akhil Soman} and Tovani-Palone, {Marcos Roberto} and Tran, {Bach Xuan} and Travillian, {Ravensara S.} and Manjari Tripathi and Tsegaye, {Gebiyaw Wudie} and Usman, {Muhammad Shariq} and Marco Vacante and Velazquez, {Diana Zuleika} and Narayanaswamy Venketasubramanian and Simone Vidale and Vasily Vlassov and Wang, {Yuan Pang} and Jingkai Wei and Jordan Weiss and Weldemariam, {Abrha Hailay} and Anders Wimo and Chenkai Wu and Ali Yadollahpour and Kazumasa Yamagishi and Yeshitila, {Yordanos Gizachew} and Naohiro Yonemoto and Siddhesh Zadey and Zhang, {Zhi Jiang} and Murray, {Christopher J.L.} and Theo Vos",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors.",

year = "2021",

doi = "10.1002/trc2.12200",

language = "English (US)",

volume = "7",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

issn = "2352-8737",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Global mortality from dementia

T2 - Application of a newmethod and results from the global burden of disease study 2019

AU - Nichols, Emma

AU - Abd-Allah, Foad

AU - Abdoli, Amir

AU - Abosetugn, Akine Eshete

AU - Abrha, Woldu Aberhe

AU - Abualhasan, Ahmed

AU - Abu-Gharbieh, Eman

AU - Akinyemi, Rufus Olusola

AU - Alahdab, Fares

AU - Alanezi, Fahad Mashhour

AU - Alipour, Vahid

AU - Ansari, Iman

AU - Arabloo, Jalal

AU - Ashraf-Ganjouei, Amir

AU - Avan, Abolfazl

AU - Ayano, Getinet

AU - Babar, Zaheer Ud Din

AU - Baig, Atif Amin

AU - Banach, Maciej

AU - Barboza, Miguel A.

AU - Barker-Collo, Suzanne Lyn

AU - Baune, Bernhard T.

AU - Srikanth Bhagavathula, Akshaya

AU - Bhattacharyya, Krittika

AU - Bijani, Ali

AU - Biondi, Antonio

AU - Birhan, Tsegaye Adane

AU - Biswas, Atanu

AU - Bolla, Srinivasa Rao

AU - Boloor, Archith

AU - Brayne, Carol

AU - Brenner, Hermann

AU - Burkart, Katrin

AU - Burns, Richard A.

AU - Nagaraja, Sharath Burugina

AU - Carvalho, Felix

AU - Castro-De-araujo, Luis F.S.

AU - Catalá-López, Ferrán

AU - Cerin, Ester

AU - Cernigliaro, Achille

AU - Cherbuin, Nicolas

AU - Jasmine Choi, Jee Young

AU - Chu, Dinh Toi

AU - Dagnew, Baye

AU - Dai, Xiaochen

AU - Dandona, Lalit

AU - Dandona, Rakhi

AU - Diaz, Daniel

AU - Dibaji Forooshani, Zahra Sadat

AU - Douiri, Abdel

AU - Duncan, Bruce B.

AU - Edvardsson, David

AU - El-Jaafary, Shaimaa I.

AU - Eskandari, Khalil

AU - Eskandarieh, Sharareh

AU - Feigin, Valery L.

AU - Fereshtehnejad, Seyed Mohammad

AU - Fernandes, Eduarda

AU - Ferrara, Pietro

AU - Filip, Irina

AU - Fischer, Florian

AU - Gaidhane, Shilpa

AU - Gebregzabiher, Kidane Zereabruk

AU - Ghashghaee, Ahmad

AU - Gholamian, Asadollah

AU - Gnedovskaya, Elena V.

AU - Golechha, Mahaveer

AU - Gupta, Rajeev

AU - Hachinski, Vladimir

AU - Hamidi, Samer

AU - Hankey, Graeme J.

AU - Haro, Josep Maria

AU - Hassan, Amr

AU - Hay, Simon I.

AU - Heidari, Golnaz

AU - Heidari-Soureshjani, Reza

AU - Househ, Mowafa

AU - Hussain, Rabia

AU - Hwang, Bing Fang

AU - Ilic, Irena M.

AU - Ilic, Milena D.

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PY - 2021

Y1 - 2021

N2 - Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

AB - Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

KW - Burden of disease

KW - Dementia

KW - Global health

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=85120037485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85120037485&partnerID=8YFLogxK

U2 - 10.1002/trc2.12200

DO - 10.1002/trc2.12200

M3 - Article

C2 - 34337138

AN - SCOPUS:85120037485

SN - 2352-8737

VL - 7

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

M1 - e12200

ER -

Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019

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