Global shapes of F-actin depolymerization-competent minimal gelsolins: Insight into the role of g2-g3 linker in pH/Ca2+ insensitivity of the first half

Nagesh Peddada, Amin Sagar, Yogendra S. Rathore, Vikas Choudhary, U. Bharat K. Pattnaik, Neeraj Khatri, Renu Garg, Ashish

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Shape-function studies are necessary to design better therapeutic alternatives of the plasma gelsolin. Results: N-terminal fragment 30-161 is the smallest segment with F-actin depolymerization potential, and G1-G3 can function independent of Ca2+ ions or low pH. Conclusion: The g2-g3 linker plays a role in imparting pH/Ca2+ insensitivity to G1-G3. Significance: We provide the first evidence that g2-g3 linker regulates mobility of the G1 domain.

Original languageEnglish (US)
Pages (from-to)28266-28282
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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