Glomerular architectural changes after a two-hour infusion of norepinephrine

R. E. Bulger, R. E. Cronin, D. C. Dobyan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Alterations in glomerular architecture have been suggested to play a role in the pathogenesis of several models of acute renal failure. In this study, mongrel dogs were subjected to an intrarenal infusion of norepinephrine for 2 hours. Light microscopy and scanning and transmission electron microscopy were used to describe glomerular architecture 2 days after the initial norepinephrine infusion. In addition, scanning electron microscopy was used to quantitate the percentage of 'abnormal areas' in glomerular capillary-loop morphology in both norepinephrine-infused kidneys and the contralateral control kidneys. Alterations in glomerular structure in these experiments appeared to be much less extensive than previously reported. A variable amount of glomerular pedical shape simplification was seen, which involved about 15% of the capillary loop. Quantitative evaluation revealed abnormal morphology of 15.2% ± 0.6% of the glomerular capillary loop in the norepinephrine-infused kidneys, compared to 2.9 ‰ ± 0.4 abnormal loop structure in the contralateral control kidneys (P<0.001). It is concluded that alterations in glomerular structure are not extensive in this model.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalAmerican Journal of Anatomy
Volume159
Issue number4
StatePublished - 1980

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Norepinephrine
Kidney
Scanning Transmission Electron Microscopy
Acute Kidney Injury
Electron Scanning Microscopy
Microscopy
Dogs
Light

ASJC Scopus subject areas

  • Anatomy

Cite this

Bulger, R. E., Cronin, R. E., & Dobyan, D. C. (1980). Glomerular architectural changes after a two-hour infusion of norepinephrine. American Journal of Anatomy, 159(4), 379-384.

Glomerular architectural changes after a two-hour infusion of norepinephrine. / Bulger, R. E.; Cronin, R. E.; Dobyan, D. C.

In: American Journal of Anatomy, Vol. 159, No. 4, 1980, p. 379-384.

Research output: Contribution to journalArticle

Bulger, RE, Cronin, RE & Dobyan, DC 1980, 'Glomerular architectural changes after a two-hour infusion of norepinephrine', American Journal of Anatomy, vol. 159, no. 4, pp. 379-384.
Bulger, R. E. ; Cronin, R. E. ; Dobyan, D. C. / Glomerular architectural changes after a two-hour infusion of norepinephrine. In: American Journal of Anatomy. 1980 ; Vol. 159, No. 4. pp. 379-384.
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