Glomerular lesions in HIV-infected patients

Elizabeth M. Wrone, Hugh Carey, Robert F. Reilly

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

HIV-associated nephropathy (HIVAN) is a clinicopathologic entity characterized by heavy proteinuria, absence of edema and an irreversible decline in renal function. Findings on renal biopsy include: collapsed glomerular capillaries; visceral glomerular epitheliosis; microcystic tubules; mesangial prominence; and endothelial tubuloreticular inclusions. Early in the AIDS epidemic, HIVAN was the predominant glomerular lesion observed in HIV-infected patients. It is being increasingly recognized, especially in Caucasian populations, that a variety of immune complex- mediated lesions such as membranoproliferative glomerulonephritis, proliferative glomerulonephritis and IgA nephropathy are associated with HIV infection. In this review we present two cases: one patient whose first presentation of AIDS was end-stage renal disease, who on biopsy was found to have HIVAN, and the second, who was infected with HIV, and on biopsy was found to have hepatitis C-related hepatitis C related membranoproliferative glomerulonephritis. We also review the current literature on HIVAN and HIV- associated immune complex diseases (HIVICDs). Each case illustrates an important clinical point. The first that renal disease can be the first manifestation of HIV infection and the second that HIV-infected patients may develop immune complex related renal diseases, some of which may be potentially treatable.

Original languageEnglish (US)
Pages (from-to)161-173
Number of pages13
JournalYale Journal of Biology and Medicine
Volume70
Issue number2
StatePublished - Mar 1997

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AIDS-Associated Nephropathy
Biopsy
Antigen-Antibody Complex
HIV
Membranoproliferative Glomerulonephritis
Kidney
Hepatitis C
HIV Infections
Acquired Immunodeficiency Syndrome
Immune Complex Diseases
Glomerulonephritis
Proteinuria
Immunoglobulin A
Chronic Kidney Failure
Edema
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Glomerular lesions in HIV-infected patients. / Wrone, Elizabeth M.; Carey, Hugh; Reilly, Robert F.

In: Yale Journal of Biology and Medicine, Vol. 70, No. 2, 03.1997, p. 161-173.

Research output: Contribution to journalArticle

Wrone, Elizabeth M. ; Carey, Hugh ; Reilly, Robert F. / Glomerular lesions in HIV-infected patients. In: Yale Journal of Biology and Medicine. 1997 ; Vol. 70, No. 2. pp. 161-173.
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