Glucagon and diabetes

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We have considered the evidence, first that the presence of glucagon is essential in the pathogenesis of the full syndrome that results from complete insulin deficiency; second, that in the diabetic in whom insulin levels are relatively fixed, a rise in glucagon concentration contributes to endogenous hyperglycemia; and, third, that conventional methods of treatment of diabetes do not fully correct either the abnormal glucagon levels or the hyperglycemia, but when insulin therapy is supplemented with somatostatin, an agent which suppresses both glucagon and growth hormone, both hyperglycemia and hyperglucagonemia are corrected. These facts may one day provide a rationale for therapeutic efforts to suppress excess glucagon secretion in the management of diabetes in man.

Original languageEnglish (US)
Pages (from-to)713-722
Number of pages10
JournalMedical Clinics of North America
Volume62
Issue number4
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Medicine(all)

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