Glucagon: Role in the hyperglycemia of diabetes mellitus

R. Dobbs; H. Sakurai; H. Sasaki; G. Faloona; I. Valverde; D. Baetens; L. Orci; Roger H Unger

doi:10.1126/science.1089999

Glucagon: Role in the hyperglycemia of diabetes mellitus

R. Dobbs, H. Sakurai, H. Sasaki, G. Faloona, I. Valverde, D. Baetens, L. Orci, Roger H Unger

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Abstract

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.

Original language	English (US)
Pages (from-to)	544-547
Number of pages	4
Journal	Science
Volume	187
Issue number	4176
DOIs	https://doi.org/10.1126/science.1089999
State	Published - 1975

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abstract = "Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.",

author = "R. Dobbs and H. Sakurai and H. Sasaki and G. Faloona and I. Valverde and D. Baetens and L. Orci and Unger, {Roger H}",

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AU - Sakurai, H.

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AU - Baetens, D.

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AU - Unger, Roger H

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AB - Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.

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Glucagon: Role in the hyperglycemia of diabetes mellitus

Abstract

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