Glucagon: Role in the hyperglycemia of diabetes mellitus

R. Dobbs, H. Sakurai, H. Sasaki, G. Faloona, I. Valverde, D. Baetens, L. Orci, Roger H Unger

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalScience
Volume187
Issue number4176
StatePublished - 1975

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Glucagon
Hyperglycemia
Diabetes Mellitus
Somatostatin
Insulin
Alloxan
Pancreatectomy
Dogs
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., ... Unger, R. H. (1975). Glucagon: Role in the hyperglycemia of diabetes mellitus. Science, 187(4176), 544-547.

Glucagon : Role in the hyperglycemia of diabetes mellitus. / Dobbs, R.; Sakurai, H.; Sasaki, H.; Faloona, G.; Valverde, I.; Baetens, D.; Orci, L.; Unger, Roger H.

In: Science, Vol. 187, No. 4176, 1975, p. 544-547.

Research output: Contribution to journalArticle

Dobbs, R, Sakurai, H, Sasaki, H, Faloona, G, Valverde, I, Baetens, D, Orci, L & Unger, RH 1975, 'Glucagon: Role in the hyperglycemia of diabetes mellitus', Science, vol. 187, no. 4176, pp. 544-547.
Dobbs R, Sakurai H, Sasaki H, Faloona G, Valverde I, Baetens D et al. Glucagon: Role in the hyperglycemia of diabetes mellitus. Science. 1975;187(4176):544-547.
Dobbs, R. ; Sakurai, H. ; Sasaki, H. ; Faloona, G. ; Valverde, I. ; Baetens, D. ; Orci, L. ; Unger, Roger H. / Glucagon : Role in the hyperglycemia of diabetes mellitus. In: Science. 1975 ; Vol. 187, No. 4176. pp. 544-547.
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