Glucagon: Role in the hyperglycemia of diabetes mellitus

R. Dobbs, H. Sakurai, H. Sasaki, G. Faloona, I. Valverde, D. Baetens, L. Orci, Roger H Unger

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Abstract

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalScience
Volume187
Issue number4176
DOIs
StatePublished - 1975

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    Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., & Unger, R. H. (1975). Glucagon: Role in the hyperglycemia of diabetes mellitus. Science, 187(4176), 544-547. https://doi.org/10.1126/science.1089999