Glucagon: Role in the hyperglycemia of diabetes mellitus

R. Dobbs, H. Sakurai, H. Sasaki, G. Faloona, I. Valverde, D. Baetens, L. Orci, Roger H Unger

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalScience
Volume187
Issue number4176
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • General

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