Glucocorticoid receptor and interleukin-1 receptor messenger RNA expression in corneal cells

S. E. Wilson, S. A. Lloyd, Y. G. He

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Interleukin-1 receptor and glucocorticoid receptor messenger ribonucleic acid (RNA) sequences coding for the corresponding proteins were detected in corneal epithelium, stromal fibroblast, and endothelial cells using the polymerase-chain reaction and hot blotting. Identification of interleukin-1 receptor mRNA in each of the three major cell types of the cornea suggests that interleukin-1 α has autocrine and/or paracrine roles in the cornea, since previous studies have found that interleukin-1 α mRNA is produced in corneal epithelial, stromal fibroblast, and endothelial cells. Further investigation is needed to determine the functions regulated by the interleukin-1 receptor and glucocorticoid receptor in the cornea and the role of each in corneal wound healing.

Original languageEnglish (US)
Pages (from-to)4-8
Number of pages5
JournalCornea
Volume13
Issue number1
DOIs
StatePublished - 1994

Fingerprint

Interleukin-1 Receptors
Glucocorticoid Receptors
Cornea
RNA
Stromal Cells
Interleukin-1
Endothelial Cells
Fibroblasts
Messenger RNA
Corneal Epithelium
Wound Healing
Polymerase Chain Reaction
Proteins

Keywords

  • Cornea
  • Corneal endothelium
  • Corneal epithelium
  • Glucocorticoids
  • Growth factors
  • Interleukin-1 α
  • Interleukin-1 receptor

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Glucocorticoid receptor and interleukin-1 receptor messenger RNA expression in corneal cells. / Wilson, S. E.; Lloyd, S. A.; He, Y. G.

In: Cornea, Vol. 13, No. 1, 1994, p. 4-8.

Research output: Contribution to journalArticle

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