Abstract
Interleukin-1 receptor and glucocorticoid receptor messenger ribonucleic acid (RNA) sequences coding for the corresponding proteins were detected in corneal epithelium, stromal fibroblast, and endothelial cells using the polymerase-chain reaction and hot blotting. Identification of interleukin-1 receptor mRNA in each of the three major cell types of the cornea suggests that interleukin-1 α has autocrine and/or paracrine roles in the cornea, since previous studies have found that interleukin-1 α mRNA is produced in corneal epithelial, stromal fibroblast, and endothelial cells. Further investigation is needed to determine the functions regulated by the interleukin-1 receptor and glucocorticoid receptor in the cornea and the role of each in corneal wound healing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4-8 |
| Number of pages | 5 |
| Journal | Cornea |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
Keywords
- Cornea
- Corneal endothelium
- Corneal epithelium
- Glucocorticoids
- Growth factors
- Interleukin-1 receptor
- Interleukin-1 α
ASJC Scopus subject areas
- Ophthalmology