Glucocorticoid receptor and interleukin-1 receptor messenger RNA expression in corneal cells

S. E. Wilson, S. A. Lloyd, Y. G. He

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Interleukin-1 receptor and glucocorticoid receptor messenger ribonucleic acid (RNA) sequences coding for the corresponding proteins were detected in corneal epithelium, stromal fibroblast, and endothelial cells using the polymerase-chain reaction and hot blotting. Identification of interleukin-1 receptor mRNA in each of the three major cell types of the cornea suggests that interleukin-1 α has autocrine and/or paracrine roles in the cornea, since previous studies have found that interleukin-1 α mRNA is produced in corneal epithelial, stromal fibroblast, and endothelial cells. Further investigation is needed to determine the functions regulated by the interleukin-1 receptor and glucocorticoid receptor in the cornea and the role of each in corneal wound healing.

Original languageEnglish (US)
Pages (from-to)4-8
Number of pages5
JournalCornea
Volume13
Issue number1
DOIs
StatePublished - Jan 11 1994

Keywords

  • Cornea
  • Corneal endothelium
  • Corneal epithelium
  • Glucocorticoids
  • Growth factors
  • Interleukin-1 receptor
  • Interleukin-1 α

ASJC Scopus subject areas

  • Ophthalmology

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