TY - JOUR
T1 - Glucocorticoid receptor expression in breast cancer associates with older patient age
AU - Belova, Larissa
AU - Delgado, Bertha
AU - Kocherginsky, Masha
AU - Melhem, Amal
AU - Olopade, Olufunmilayo I.
AU - Conzen, Suzanne D.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants 5R01CA089208-06, 5P50ES012382-05, 5P50CA 125183-02 and the Women’s Auxiliary Board of the University of Chicago Cancer Center.
PY - 2009/8
Y1 - 2009/8
N2 - Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.
AB - Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.
KW - Estrogen receptor
KW - Glucocorticoid receptor
KW - HER2
KW - Health disparities
KW - Progesterone receptor
KW - Triple-negative disease
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U2 - 10.1007/s10549-008-0136-9
DO - 10.1007/s10549-008-0136-9
M3 - Article
C2 - 18668364
AN - SCOPUS:70349570432
SN - 0167-6806
VL - 116
SP - 441
EP - 447
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 3
ER -