Glucocorticoid receptor expression in breast cancer associates with older patient age

Larissa Belova, Bertha Delgado, Masha Kocherginsky, Amal Melhem, Olufunmilayo I. Olopade, Suzanne D. Conzen

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients ≥50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to longterm clinical outcome.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalBreast Cancer Research and Treatment
Volume116
Issue number3
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Keywords

  • Estrogen receptor
  • Glucocorticoid receptor
  • HER2
  • Health disparities
  • Progesterone receptor
  • Triple-negative disease

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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