Glucocorticoids

Potent inhibitors and stimulators of growth hormone secretion

W. B. Wehrenberg, B. A. Janowski, A. W. Piering, F. Culler, K. L. Jones

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Excessive glucocorticoid concentrations are well recognized inhibitors of linear growth, due in part to their suppression of GH secretion. The mechanism of this inhibition has been unclear, especially since glucocorticoids enhance the in vitro GH response of pituitary cells to GH-releasing hormone (GHRH). We investigated the possibility that hypothalamic somatostatin might be mediating these dichotomous observations by using passive immunization techniques. The GH response to GHRH was significantly blunted in rats pretreated with the synthetic glucocorticoid, dexamethasone, compared to that in normal animals. In marked contrast, the immunoneutralization of somatostatin resulted in a significantly enhanced GH response to GHRH in dexamethasone-treated animals. These results suggest that the previously described inhibitory action of glucocorticoids on GH secretion in vivo are mediated via altered hypothalamic somatostatin tone.

Original languageEnglish (US)
Pages (from-to)3200-3203
Number of pages4
JournalEndocrinology
Volume126
Issue number6
StatePublished - Jun 1990

Fingerprint

Glucocorticoids
Growth Hormone
Somatostatin
Somatotrophs
Hormones
Dexamethasone
Growth Inhibitors
Passive Immunization

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Wehrenberg, W. B., Janowski, B. A., Piering, A. W., Culler, F., & Jones, K. L. (1990). Glucocorticoids: Potent inhibitors and stimulators of growth hormone secretion. Endocrinology, 126(6), 3200-3203.

Glucocorticoids : Potent inhibitors and stimulators of growth hormone secretion. / Wehrenberg, W. B.; Janowski, B. A.; Piering, A. W.; Culler, F.; Jones, K. L.

In: Endocrinology, Vol. 126, No. 6, 06.1990, p. 3200-3203.

Research output: Contribution to journalArticle

Wehrenberg, WB, Janowski, BA, Piering, AW, Culler, F & Jones, KL 1990, 'Glucocorticoids: Potent inhibitors and stimulators of growth hormone secretion', Endocrinology, vol. 126, no. 6, pp. 3200-3203.
Wehrenberg WB, Janowski BA, Piering AW, Culler F, Jones KL. Glucocorticoids: Potent inhibitors and stimulators of growth hormone secretion. Endocrinology. 1990 Jun;126(6):3200-3203.
Wehrenberg, W. B. ; Janowski, B. A. ; Piering, A. W. ; Culler, F. ; Jones, K. L. / Glucocorticoids : Potent inhibitors and stimulators of growth hormone secretion. In: Endocrinology. 1990 ; Vol. 126, No. 6. pp. 3200-3203.
@article{32773d9386994aa090d44d4ece62f7eb,
title = "Glucocorticoids: Potent inhibitors and stimulators of growth hormone secretion",
abstract = "Excessive glucocorticoid concentrations are well recognized inhibitors of linear growth, due in part to their suppression of GH secretion. The mechanism of this inhibition has been unclear, especially since glucocorticoids enhance the in vitro GH response of pituitary cells to GH-releasing hormone (GHRH). We investigated the possibility that hypothalamic somatostatin might be mediating these dichotomous observations by using passive immunization techniques. The GH response to GHRH was significantly blunted in rats pretreated with the synthetic glucocorticoid, dexamethasone, compared to that in normal animals. In marked contrast, the immunoneutralization of somatostatin resulted in a significantly enhanced GH response to GHRH in dexamethasone-treated animals. These results suggest that the previously described inhibitory action of glucocorticoids on GH secretion in vivo are mediated via altered hypothalamic somatostatin tone.",
author = "Wehrenberg, {W. B.} and Janowski, {B. A.} and Piering, {A. W.} and F. Culler and Jones, {K. L.}",
year = "1990",
month = "6",
language = "English (US)",
volume = "126",
pages = "3200--3203",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Glucocorticoids

T2 - Potent inhibitors and stimulators of growth hormone secretion

AU - Wehrenberg, W. B.

AU - Janowski, B. A.

AU - Piering, A. W.

AU - Culler, F.

AU - Jones, K. L.

PY - 1990/6

Y1 - 1990/6

N2 - Excessive glucocorticoid concentrations are well recognized inhibitors of linear growth, due in part to their suppression of GH secretion. The mechanism of this inhibition has been unclear, especially since glucocorticoids enhance the in vitro GH response of pituitary cells to GH-releasing hormone (GHRH). We investigated the possibility that hypothalamic somatostatin might be mediating these dichotomous observations by using passive immunization techniques. The GH response to GHRH was significantly blunted in rats pretreated with the synthetic glucocorticoid, dexamethasone, compared to that in normal animals. In marked contrast, the immunoneutralization of somatostatin resulted in a significantly enhanced GH response to GHRH in dexamethasone-treated animals. These results suggest that the previously described inhibitory action of glucocorticoids on GH secretion in vivo are mediated via altered hypothalamic somatostatin tone.

AB - Excessive glucocorticoid concentrations are well recognized inhibitors of linear growth, due in part to their suppression of GH secretion. The mechanism of this inhibition has been unclear, especially since glucocorticoids enhance the in vitro GH response of pituitary cells to GH-releasing hormone (GHRH). We investigated the possibility that hypothalamic somatostatin might be mediating these dichotomous observations by using passive immunization techniques. The GH response to GHRH was significantly blunted in rats pretreated with the synthetic glucocorticoid, dexamethasone, compared to that in normal animals. In marked contrast, the immunoneutralization of somatostatin resulted in a significantly enhanced GH response to GHRH in dexamethasone-treated animals. These results suggest that the previously described inhibitory action of glucocorticoids on GH secretion in vivo are mediated via altered hypothalamic somatostatin tone.

UR - http://www.scopus.com/inward/record.url?scp=0025347916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025347916&partnerID=8YFLogxK

M3 - Article

VL - 126

SP - 3200

EP - 3203

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -