TY - JOUR
T1 - Glutamine and cancer
T2 - Cell biology, physiology, and clinical opportunities
AU - Hensley, Christopher T.
AU - Wasti, Ajla T.
AU - DeBerardinis, Ralph J.
PY - 2013/9/3
Y1 - 2013/9/3
N2 - Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches.
AB - Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches.
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U2 - 10.1172/JCI69600
DO - 10.1172/JCI69600
M3 - Review article
C2 - 23999442
AN - SCOPUS:84883497454
SN - 0021-9738
VL - 123
SP - 3678
EP - 3684
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 9
ER -