Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines

Rashmi Sharma, Sharad S. Singhal, Sanjay K. Srivastava, Krishna K. Bajpai, Eugene P. Frenkel, Sanjay Awasthi

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Glutathione levels and several glutathione-linked enzyme activities have been variably correlated with cisplatin chemosensitivity in cultured neoplastic cells. In order to determine the relative contribution of the glutathione-linked enzymes towards mediating inherent cisplatin resistance in cancer cells, we have measured the chemosensitivity to cisplatin, glutathione levels and activities of glutathione S-transferase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in 8 cultured human small cell lung cance (SCLC) cell lines with widely differing cisplatin sensitivities. Of these parameters, only glutathione S-transferase activity correlated with degree of cisplatin resistance in a linear fashion.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalCancer Letters
Volume75
Issue number2
DOIs
StatePublished - Dec 10 1993

Keywords

  • Cisplatin
  • Drug resistance
  • Glutathione
  • Glutathione S-transferase
  • Small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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