Glutathione-coated luminescent gold nanoparticles: A surface ligand for minimizing serum protein adsorption

Rodrigo D. Vinluan, Jinbin Liu, Chen Zhou, Mengxiao Yu, Shengyang Yang, Amit Kumar, Shasha Sun, Andrew Dean, Xiankai Sun, Jie Zheng

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Ultrasmall glutathione-coated luminescent gold nanoparticles (GS-AuNPs) are known for their high resistance to serum protein adsorption. Our studies show that these NPs can serve as surface ligands to significantly enhance the physiological stability and lower the serum protein adsorption of superparamagnetic iron oxide nanoparticles (SPIONs), in addition to rendering the NPs the luminescence property. After the incorporation of GS-AuNPs onto the surface of SPIONs to form the hybrid nanoparticles (HBNPs), these SPIONs protein adsorption was about 10-fold lower than those of the pure glutathione-coated SPIONs suggesting that GS-AuNPs are capable of providing a stealth effect against serum proteins.

Original languageEnglish (US)
Pages (from-to)11829-11833
Number of pages5
JournalACS Applied Materials and Interfaces
Volume6
Issue number15
DOIs
StatePublished - Aug 13 2014

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Keywords

  • hybrid nanoparticles
  • integrated
  • iron oxide
  • luminescent gold nanoparticles

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Vinluan, R. D., Liu, J., Zhou, C., Yu, M., Yang, S., Kumar, A., Sun, S., Dean, A., Sun, X., & Zheng, J. (2014). Glutathione-coated luminescent gold nanoparticles: A surface ligand for minimizing serum protein adsorption. ACS Applied Materials and Interfaces, 6(15), 11829-11833. https://doi.org/10.1021/am5031374