Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Roger H Unger; Philipp E Scherer

doi:10.1016/j.tem.2010.01.009

Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Roger H Unger, Philipp E Scherer

Research output: Contribution to journal › Review article › peer-review

319 Scopus citations

Abstract

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

Original language	English (US)
Pages (from-to)	345-352
Number of pages	8
Journal	Trends in Endocrinology and Metabolism
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.tem.2010.01.009
State	Published - Jun 2010

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2010.01.009

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title = "Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity",

abstract = "Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.",

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AB - Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

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Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Abstract

ASJC Scopus subject areas

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