Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Research output: Contribution to journalReview article

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Abstract

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number6
DOIs
StatePublished - Jun 1 2010

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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