Glycoproteins, N-Linked

Research output: Chapter in Book/Report/Conference proceedingChapter


Proteins that are either secreted from eukaryotic cells or expressed on their surfaces are usually modified with structures called asparagine-linked, or N-linked, oligosaccharides. These are short sugar polymers or glycans attached to the nitrogen atoms of asparaginyl residues. The resulting glycan-protein conjugates are termed N-linked glycoproteins. There are many different kinds of N-linked oligosaccharides with roles in a wide array of biological functions, and a basic knowledge of the pathways responsible for their synthesis is necessary to understand these functions. This article covers the key concepts behind the synthesis, structures, analysis, functions, and diseases of N-linked glycoproteins, and illustrates concepts with well-established examples from the literature.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages8
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
Publication statusPublished - Feb 15 2013



  • Dolichol
  • Glycan
  • Glycobiology
  • Glycoprotein
  • Glycosidase
  • Glycosylation
  • Glycosyltransferase
  • Lectin
  • Oligosaccharide
  • Polyisoprenol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lehrman, M. A. (2013). Glycoproteins, N-Linked. In Encyclopedia of Biological Chemistry: Second Edition (pp. 457-464). Elsevier Inc..