Glycoproteins, N-Linked

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Proteins that are either secreted from eukaryotic cells or expressed on their surfaces are usually modified with structures called asparagine-linked, or N-linked, oligosaccharides. These are short sugar polymers or glycans attached to the nitrogen atoms of asparaginyl residues. The resulting glycan-protein conjugates are termed N-linked glycoproteins. There are many different kinds of N-linked oligosaccharides with roles in a wide array of biological functions, and a basic knowledge of the pathways responsible for their synthesis is necessary to understand these functions. This article covers the key concepts behind the synthesis, structures, analysis, functions, and diseases of N-linked glycoproteins, and illustrates concepts with well-established examples from the literature.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages457-464
Number of pages8
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • Dolichol
  • Glycan
  • Glycobiology
  • Glycoprotein
  • Glycosidase
  • Glycosylation
  • Glycosyltransferase
  • Lectin
  • Oligosaccharide
  • Polyisoprenol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lehrman, M. A. (2013). Glycoproteins, N-Linked. In Encyclopedia of Biological Chemistry: Second Edition (pp. 457-464). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00115-8