GM-CSF regulation in eosinophils

Stéphane Esnault, James S. Malter

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume50
Issue number2
StatePublished - Dec 1 2002

Keywords

  • Asthma
  • Eosinophils
  • GM-CSF
  • Survival
  • mRNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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