Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.
|Original language||English (US)|
|Number of pages||10|
|Journal||Archivum Immunologiae et Therapiae Experimentalis|
|State||Published - Dec 1 2002|
ASJC Scopus subject areas
- Immunology and Allergy