GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?

Matthew G. Field; J. William Harbour

doi:10.1016/j.ccr.2014.05.028

GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?

Matthew G. Field, J. William Harbour

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.

Original language	English (US)
Pages (from-to)	714-715
Number of pages	2
Journal	Cancer Cell
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.ccr.2014.05.028
State	Published - Jun 16 2014
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

Access to Document

10.1016/j.ccr.2014.05.028

Cite this

@article{557e200e04e641c3ae4424191c89d834,

title = "GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?",

abstract = "GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.",

author = "Field, {Matthew G.} and Harbour, {J. William}",

year = "2014",

month = jun,

day = "16",

doi = "10.1016/j.ccr.2014.05.028",

language = "English (US)",

volume = "25",

pages = "714--715",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - GNAQ/11 mutations in uveal melanoma

T2 - Is YAP the key to targeted therapy?

AU - Field, Matthew G.

AU - Harbour, J. William

PY - 2014/6/16

Y1 - 2014/6/16

N2 - GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.

AB - GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.

UR - http://www.scopus.com/inward/record.url?scp=84902438092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902438092&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2014.05.028

DO - 10.1016/j.ccr.2014.05.028

M3 - Short survey

C2 - 24937456

AN - SCOPUS:84902438092

SN - 1535-6108

VL - 25

SP - 714

EP - 715

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this