Gold nanocages covered by smart polymers for controlled release with near-infrared light

Mustafa S. Yavuz, Yiyun Cheng, Jingyi Chen, Claire M. Cobley, Qiang Zhang, Matthew Rycenga, Jingwei Xie, Chulhong Kim, Kwang H. Song, Andrea G. Schwartz, Lihong V. Wang, Younan Xia

Research output: Contribution to journalArticle

1000 Citations (Scopus)

Abstract

Photosensitive caged compounds have enhanced our ability to address the complexity of biological systems by generating effectors with remarkable spatial/temporal resolutions. The caging effect is typically removed by photolysis with ultraviolet light to liberate the bioactive species. Although this technique has been successfully applied to many biological problems, it suffers from a number of intrinsic drawbacks. For example, it requires dedicated efforts to design and synthesize a precursor compound for each effector. The ultraviolet light may cause damage to biological samples and is suitable only for invitro studies because of its quick attenuation in tissue. Here we address these issues by developing a platform based on the photothermal effect of gold nanocages. Gold nanocages represent a class of nanostructures with hollow interiors and porous walls. They can have strong absorption (for the photothermal effect) in the near-infrared while maintaining a compact size. When the surface of a gold nanocage is covered with a smart polymer, the pre-loaded effector can be released in a controllable fashion using a near-infrared laser. This system works well with various effectors without involving sophisticated syntheses, and is well suited for invivo studies owing to the high transparency of soft tissue in the near-infrared region.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
JournalNature Materials
Volume8
Issue number12
DOIs
StatePublished - Dec 2009

Fingerprint

effectors
Gold
Polymers
gold
Infrared radiation
polymers
ultraviolet radiation
Tissue
Infrared lasers
Photolysis
Biological systems
porous walls
Transparency
Nanostructures
activity (biology)
temporal resolution
infrared lasers
photolysis
hollow
platforms

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Yavuz, M. S., Cheng, Y., Chen, J., Cobley, C. M., Zhang, Q., Rycenga, M., ... Xia, Y. (2009). Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nature Materials, 8(12), 935-939. https://doi.org/10.1038/nmat2564

Gold nanocages covered by smart polymers for controlled release with near-infrared light. / Yavuz, Mustafa S.; Cheng, Yiyun; Chen, Jingyi; Cobley, Claire M.; Zhang, Qiang; Rycenga, Matthew; Xie, Jingwei; Kim, Chulhong; Song, Kwang H.; Schwartz, Andrea G.; Wang, Lihong V.; Xia, Younan.

In: Nature Materials, Vol. 8, No. 12, 12.2009, p. 935-939.

Research output: Contribution to journalArticle

Yavuz, MS, Cheng, Y, Chen, J, Cobley, CM, Zhang, Q, Rycenga, M, Xie, J, Kim, C, Song, KH, Schwartz, AG, Wang, LV & Xia, Y 2009, 'Gold nanocages covered by smart polymers for controlled release with near-infrared light', Nature Materials, vol. 8, no. 12, pp. 935-939. https://doi.org/10.1038/nmat2564
Yavuz MS, Cheng Y, Chen J, Cobley CM, Zhang Q, Rycenga M et al. Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nature Materials. 2009 Dec;8(12):935-939. https://doi.org/10.1038/nmat2564
Yavuz, Mustafa S. ; Cheng, Yiyun ; Chen, Jingyi ; Cobley, Claire M. ; Zhang, Qiang ; Rycenga, Matthew ; Xie, Jingwei ; Kim, Chulhong ; Song, Kwang H. ; Schwartz, Andrea G. ; Wang, Lihong V. ; Xia, Younan. / Gold nanocages covered by smart polymers for controlled release with near-infrared light. In: Nature Materials. 2009 ; Vol. 8, No. 12. pp. 935-939.
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