Gold nanoprobes for multi-modality tumor imaging

James Nyagilo, Ming Xiao, Xiankai Sun, Digant P. Davé

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ∼65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7576
DOIs
StatePublished - 2010
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II - San Francisco, CA, United States
Duration: Jan 25 2010Jan 27 2010

Other

OtherReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
CountryUnited States
CitySan Francisco, CA
Period1/25/101/27/10

Fingerprint

Nanoprobes
Gold
Nanoparticles
Tumors
tumors
Raman Spectrum Analysis
gold
Imaging techniques
nanoparticles
Raman scattering
X-Rays
Neoplasms
Raman spectra
X rays
Surface phenomena
animal models
Iodine
x ray absorption
scattering cross sections
Contrast Media

Keywords

  • Computed tomography
  • Gold nanoparticles
  • Orthotropic
  • Surface enhanced Raman scattering
  • Tumor

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Nyagilo, J., Xiao, M., Sun, X., & Davé, D. P. (2010). Gold nanoprobes for multi-modality tumor imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7576). [75760X] https://doi.org/10.1117/12.842917

Gold nanoprobes for multi-modality tumor imaging. / Nyagilo, James; Xiao, Ming; Sun, Xiankai; Davé, Digant P.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7576 2010. 75760X.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nyagilo, J, Xiao, M, Sun, X & Davé, DP 2010, Gold nanoprobes for multi-modality tumor imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7576, 75760X, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, San Francisco, CA, United States, 1/25/10. https://doi.org/10.1117/12.842917
Nyagilo J, Xiao M, Sun X, Davé DP. Gold nanoprobes for multi-modality tumor imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7576. 2010. 75760X https://doi.org/10.1117/12.842917
Nyagilo, James ; Xiao, Ming ; Sun, Xiankai ; Davé, Digant P. / Gold nanoprobes for multi-modality tumor imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7576 2010.
@inproceedings{49302da24d76413cac37d90b77c1e0c9,
title = "Gold nanoprobes for multi-modality tumor imaging",
abstract = "Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ∼65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.",
keywords = "Computed tomography, Gold nanoparticles, Orthotropic, Surface enhanced Raman scattering, Tumor",
author = "James Nyagilo and Ming Xiao and Xiankai Sun and Dav{\'e}, {Digant P.}",
year = "2010",
doi = "10.1117/12.842917",
language = "English (US)",
isbn = "9780819479723",
volume = "7576",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Gold nanoprobes for multi-modality tumor imaging

AU - Nyagilo, James

AU - Xiao, Ming

AU - Sun, Xiankai

AU - Davé, Digant P.

PY - 2010

Y1 - 2010

N2 - Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ∼65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.

AB - Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ∼65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.

KW - Computed tomography

KW - Gold nanoparticles

KW - Orthotropic

KW - Surface enhanced Raman scattering

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=77951795409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951795409&partnerID=8YFLogxK

U2 - 10.1117/12.842917

DO - 10.1117/12.842917

M3 - Conference contribution

AN - SCOPUS:77951795409

SN - 9780819479723

VL - 7576

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -