Gold nanotags for combined multi-colored Raman spectroscopy and x-ray computed tomography

Ming Xiao, James Nyagilo, Veera Arora, Padmakar Kulkarni, Dongsheng Xu, Xiankai Sun, Digant P. Davé

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Multi-color gold-nanoparticle-based tags (nanotags) are synthesized for combined surface-enhanced Raman spectroscopy (SERS) and x-ray computed tomography (CT). The nanotags are synthesized with quasi-spherical gold nanoparticles encoded with a reporter dye (color), each with a unique Raman spectrum. A library of nanotags with six different colors were synthesized for a range of gold nanoparticle sizes and an optimum size has been established to yield the largest SERS intensity and x-ray attenuation that is higher than the iodinated CT contrast agents used in clinics. Proof-of-principle in vivo imaging results with nanotags are presented that, for the first time, demonstrates the combined in vivo dual modality imaging capability of SERS and CT with a single nanoparticle probe.

Original languageEnglish (US)
Article number035101
JournalNanotechnology
Volume21
Issue number3
DOIs
StatePublished - Jan 29 2010

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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