Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low, Ronald M. Lechan, Robert E Hammer, Ralph L. Brinster, Joel F. Habener, Gail Mandel, Richard H. Goodman

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

Original languageEnglish (US)
Pages (from-to)1002-1004
Number of pages3
JournalScience
Volume231
Issue number4741
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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