Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low, Ronald M. Lechan, Robert E Hammer, Ralph L. Brinster, Joel F. Habener, Gail Mandel, Richard H. Goodman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

Original languageEnglish (US)
Pages (from-to)1002-1004
Number of pages3
JournalScience
Volume231
Issue number4741
StatePublished - 1986

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Gonadotrophs
Metallothionein
Gene Fusion
Somatostatin
Transgenic Mice
Anterior Pituitary Gland
Human Growth Hormone

ASJC Scopus subject areas

  • General

Cite this

Low, M. J., Lechan, R. M., Hammer, R. E., Brinster, R. L., Habener, J. F., Mandel, G., & Goodman, R. H. (1986). Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science, 231(4741), 1002-1004.

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. / Low, Malcolm J.; Lechan, Ronald M.; Hammer, Robert E; Brinster, Ralph L.; Habener, Joel F.; Mandel, Gail; Goodman, Richard H.

In: Science, Vol. 231, No. 4741, 1986, p. 1002-1004.

Research output: Contribution to journalArticle

Low, MJ, Lechan, RM, Hammer, RE, Brinster, RL, Habener, JF, Mandel, G & Goodman, RH 1986, 'Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice', Science, vol. 231, no. 4741, pp. 1002-1004.
Low MJ, Lechan RM, Hammer RE, Brinster RL, Habener JF, Mandel G et al. Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science. 1986;231(4741):1002-1004.
Low, Malcolm J. ; Lechan, Ronald M. ; Hammer, Robert E ; Brinster, Ralph L. ; Habener, Joel F. ; Mandel, Gail ; Goodman, Richard H. / Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. In: Science. 1986 ; Vol. 231, No. 4741. pp. 1002-1004.
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