Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low; Ronald M. Lechan; Robert E Hammer; Ralph L. Brinster; Joel F. Habener; Gail Mandel; Richard H. Goodman

doi:10.1126/science.2868526

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low, Ronald M. Lechan, Robert E Hammer, Ralph L. Brinster, Joel F. Habener, Gail Mandel, Richard H. Goodman

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Abstract

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

Original language	English (US)
Pages (from-to)	1002-1004
Number of pages	3
Journal	Science
Volume	231
Issue number	4741
DOIs	https://doi.org/10.1126/science.2868526
State	Published - 1986

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title = "Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice",

abstract = "Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.",

author = "Low, {Malcolm J.} and Lechan, {Ronald M.} and Hammer, {Robert E} and Brinster, {Ralph L.} and Habener, {Joel F.} and Gail Mandel and Goodman, {Richard H.}",

year = "1986",

doi = "10.1126/science.2868526",

language = "English (US)",

volume = "231",

pages = "1002--1004",

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publisher = "American Association for the Advancement of Science",

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T1 - Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

AU - Low, Malcolm J.

AU - Lechan, Ronald M.

AU - Hammer, Robert E

AU - Brinster, Ralph L.

AU - Habener, Joel F.

AU - Mandel, Gail

AU - Goodman, Richard H.

PY - 1986

Y1 - 1986

N2 - Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

AB - Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

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IS - 4741

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Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

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