Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

Malcolm J. Low, Ronald M. Lechan, Robert E Hammer, Ralph L. Brinster, Joel F. Habener, Gail Mandel, Richard H. Goodman

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.

Original languageEnglish (US)
Pages (from-to)1002-1004
Number of pages3
JournalScience
Volume231
Issue number4741
DOIs
StatePublished - Jan 1 1986

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    Low, M. J., Lechan, R. M., Hammer, R. E., Brinster, R. L., Habener, J. F., Mandel, G., & Goodman, R. H. (1986). Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science, 231(4741), 1002-1004. https://doi.org/10.1126/science.2868526