Gonorrhea in Preschooland School-Aged Children

Report of the Prepubertal Gonorrhea Cooperative Study Group

John D. Nelson, Edgar Mohs, Adnan S. Dajani, Stanley A. Plotkin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Single-dose antibiotic therapy was evaluated in 108 episodes of culture-confirmed, uncomplicated gonorrhea in 100 prepubertal children. There were 15 boys and 85 girls between 14 months and 14 years of age. Penicillin G procaine, 100,000 units/kg intramuscularly, was compared with amoxicillin trihydrate, 50 mg/kg orally. Probenecid, 25 mg/kg, was given simultaneously. Both drugs provided prompt bacteriological and clinical response. Multiple episodes of gonorrhea, presumably caused by reexposure, occurred in six girls. Oral and anal cultures were negative in all of 47 Costa Rican cases but were commonly positive in US children. Anal cultures yielded gonococci in 52% of girls and 25% of boys, and oral cultures were positive in 18% and 13%, respectively. In three instances, rectal cultures confirmed the diagnosis when vaginal cultures were negative. Gonorrhea should be considered in every child with vaginal or urethral discharge. Single-dose penicillin-probenecid or amoxicillin-probenecid treatment is curative.

Original languageEnglish (US)
Pages (from-to)1359-1364
Number of pages6
JournalJAMA - Journal of the American Medical Association
Volume236
Issue number12
DOIs
StatePublished - Sep 20 1976

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Probenecid
Gonorrhea
Amoxicillin
Penicillin G Procaine
Neisseria gonorrhoeae
Penicillins
Anti-Bacterial Agents
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gonorrhea in Preschooland School-Aged Children : Report of the Prepubertal Gonorrhea Cooperative Study Group. / Nelson, John D.; Mohs, Edgar; Dajani, Adnan S.; Plotkin, Stanley A.

In: JAMA - Journal of the American Medical Association, Vol. 236, No. 12, 20.09.1976, p. 1359-1364.

Research output: Contribution to journalArticle

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