Good copy, bad copy: Choosing animal models for HLA-linked diseases

Attila Kumánovics, Kirsten Fischer Lindahl

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Recent large-scale sequencing and comparative analyses of the major histocompatibility complex (Mhc) provide a novel view of this long-studied region. The main insight is that even though Mhcs are defined by the presence of the Mhc class I and II genes, the regions encoding class I/II histocompatibility antigens are the least conserved among the species; hence the difficulty of modeling the human class I/II-linked diseases. Fortunately, the majority of the genes in the Mhc, the non-class I/II genes, are conserved among the investigated mammals. The full set of Mhc genes in their evolutionary context presents new possibilities to study Mhc-linked diseases by allowing systematic evaluation of the various experimental animals and approaches.

Original languageEnglish (US)
Pages (from-to)258-263
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2004

Keywords

  • CDSN
  • HLA
  • Mhc
  • corneodesmosin
  • human leukocyte antigen
  • major histocompatibility complex

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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