Good neighbours in the tumour stroma reduce oxidative stress

Ralph J. Deberardinis

doi:10.1038/ncb2449

Good neighbours in the tumour stroma reduce oxidative stress

Ralph J. Deberardinis

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

Original language	English (US)
Pages (from-to)	235-236
Number of pages	2
Journal	Nature cell biology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1038/ncb2449
State	Published - Mar 1 2012

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb2449

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abstract = "Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.",

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Good neighbours in the tumour stroma reduce oxidative stress

Abstract

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