Good neighbours in the tumour stroma reduce oxidative stress

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

Original languageEnglish (US)
Pages (from-to)235-236
Number of pages2
JournalNature Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Mar 2012

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Oxidative Stress
Neoplasms
Mesenchymal Stromal Cells
Oncogenes
Cysteine
Leukemia
Food
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Good neighbours in the tumour stroma reduce oxidative stress. / Deberardinis, Ralph J.

In: Nature Cell Biology, Vol. 14, No. 3, 03.2012, p. 235-236.

Research output: Contribution to journalArticle

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