GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs

Jianhua Ye, William T. Doerrler, Mark A Lehrman, J R Falck

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Analogs of GPI membrane anchor precursors were prepared from chiral inositol 1 and evaluated as substrates in rodent and trypanosomal cell-free incubates. Di-octanoyl GlcNα-PI 5b was an efficient mannose acceptor whereas di-palmitoyl GlcNα-PI 5a was unexpectedly refractory. Di-octanoyl β-anomer 8 was mannosylated only under conditions that permitted acylation of the inositol residue.

Original languageEnglish (US)
Pages (from-to)1715-1718
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number14
DOIs
StatePublished - Jul 23 1996

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Glycosylphosphatidylinositols
Inositol
Phosphatidylinositols
Acylation
Mannose
Refractory materials
Rodentia
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

GPI membrane anchors : Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs. / Ye, Jianhua; Doerrler, William T.; Lehrman, Mark A; Falck, J R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 14, 23.07.1996, p. 1715-1718.

Research output: Contribution to journalArticle

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