GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs

Jianhua Ye, William T. Doerrler, Mark A Lehrman, J R Falck

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Analogs of GPI membrane anchor precursors were prepared from chiral inositol 1 and evaluated as substrates in rodent and trypanosomal cell-free incubates. Di-octanoyl GlcNα-PI 5b was an efficient mannose acceptor whereas di-palmitoyl GlcNα-PI 5a was unexpectedly refractory. Di-octanoyl β-anomer 8 was mannosylated only under conditions that permitted acylation of the inositol residue.

Original languageEnglish (US)
Pages (from-to)1715-1718
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number14
DOIs
StatePublished - Jul 23 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs'. Together they form a unique fingerprint.

  • Cite this