GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

Dayoung Oh, Saswata Talukdar, Eun Ju Bae, Takeshi Imamura, Hidetaka Morinaga, Wu Qiang Fan, Pingping Li, Wendell J. Lu, Steven M. Watkins, Jerrold M. Olefsky

Research output: Contribution to journalArticle

1251 Citations (Scopus)

Abstract

Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an ω-3 FA receptor/sensor. Stimulation of GPR120 with ω-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown. Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without ω-3 FA supplementation. The ω-3 FA treatment inhibited inflammation and enhanced systemic insulin sensitivity in WT mice, but was without effect in GPR120 knockout mice. In conclusion, GPR120 is a functional ω-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.

Original languageEnglish (US)
Pages (from-to)687-698
Number of pages12
JournalCell
Volume142
Issue number5
DOIs
StatePublished - Sep 3 2010

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Omega-3 Fatty Acids
G-Protein-Coupled Receptors
Anti-Inflammatory Agents
Insulin
Macrophages
Inflammation
Knockout Mice
Insulin Resistance
Tissue
Sensors
High Fat Diet
Nutrition
Leptin
Hypoglycemic Agents
Obesity
Fats

Keywords

  • Humdisease
  • Signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Oh, D., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W. Q., ... Olefsky, J. M. (2010). GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. Cell, 142(5), 687-698. https://doi.org/10.1016/j.cell.2010.07.041

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. / Oh, Dayoung; Talukdar, Saswata; Bae, Eun Ju; Imamura, Takeshi; Morinaga, Hidetaka; Fan, Wu Qiang; Li, Pingping; Lu, Wendell J.; Watkins, Steven M.; Olefsky, Jerrold M.

In: Cell, Vol. 142, No. 5, 03.09.2010, p. 687-698.

Research output: Contribution to journalArticle

Oh, D, Talukdar, S, Bae, EJ, Imamura, T, Morinaga, H, Fan, WQ, Li, P, Lu, WJ, Watkins, SM & Olefsky, JM 2010, 'GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects', Cell, vol. 142, no. 5, pp. 687-698. https://doi.org/10.1016/j.cell.2010.07.041
Oh, Dayoung ; Talukdar, Saswata ; Bae, Eun Ju ; Imamura, Takeshi ; Morinaga, Hidetaka ; Fan, Wu Qiang ; Li, Pingping ; Lu, Wendell J. ; Watkins, Steven M. ; Olefsky, Jerrold M. / GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. In: Cell. 2010 ; Vol. 142, No. 5. pp. 687-698.
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