Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Thomas M. Wilkie; Michael A. Hale; Sarthak Reddy

doi:10.1016/j.ceca.2020.102340

Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Thomas M. Wilkie, Michael A. Hale, Sarthak Reddy

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

Original language	English (US)
Article number	102340
Journal	Cell Calcium
Volume	94
DOIs	https://doi.org/10.1016/j.ceca.2020.102340
State	Published - Mar 2021

Keywords

Calcium signaling
Gi signaling
Gq signaling
RGS proteins

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.ceca.2020.102340

Cite this

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title = "Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts",

abstract = "The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.",

keywords = "Calcium signaling, Gi signaling, Gq signaling, RGS proteins",

author = "Wilkie, {Thomas M.} and Hale, {Michael A.} and Sarthak Reddy",

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year = "2021",

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doi = "10.1016/j.ceca.2020.102340",

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T2 - More than the sum of its reconstituted parts

AU - Wilkie, Thomas M.

AU - Hale, Michael A.

AU - Reddy, Sarthak

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AB - The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

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KW - Gi signaling

KW - Gq signaling

KW - RGS proteins

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JO - Cell Calcium

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Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Abstract

Keywords

ASJC Scopus subject areas

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