Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Thomas M. Wilkie, Michael A. Hale, Sarthak Reddy

Research output: Contribution to journalComment/debatepeer-review

Abstract

The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

Original languageEnglish (US)
Article number102340
JournalCell Calcium
Volume94
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • Calcium signaling
  • Gi signaling
  • Gq signaling
  • RGS proteins

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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