Graft-versus-host disease impairs cerebellar growth [15]

W. S T Griffin, J. R. Head, D. J. Woodward, C. Carrol

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

THE mechanisms of mental retardation are of critical interest to both basic developmental neurobiologists and those in the clinical community concerned with perinatal development. The possibility of a deleterious immunological interaction between mother and fetus has long been recognised as a potential developmental hazard1. However, there have been no reports of specific conditions which involve immunological injury to the developing brain. Graft-versus-host disease (GVHD) is a model disease that can be induced naturally or experimentally by grafting mature, immunocompetent lymphoid cells into an immature, immunoincompetent host. The failure of the host, for example a newborn rat pup, to recognise the graft as non-self leads to an attack by the grafted cells on host lymphomyeloid tissues, resulting in many symptoms, including wasting, anaemia, alterations of lymphoid organ weights, hyperex-citability and an ataxic-like gait2. The last two features suggest possible brain dysfunctions and have motivated our investigation of immunologically induced perinatal brain injury. The rat cerebellum was used here as a model system for the study of brain alterations during GVHD because of its well known cytoarchitecture3. In addition, its postnatal development renders it sensitive to many forms of perinatal stress4,5. In this study, we demonstrate that significant alterations in the cerebellar cellular content and capacity for DNA synthesis occur in rats suffering from neonatally induced GVHD.

Original languageEnglish (US)
Pages (from-to)315-317
Number of pages3
JournalNature
Volume275
Issue number5678
DOIs
StatePublished - 1978

Fingerprint

Graft vs Host Disease
Brain
Growth
Organ Size
Intellectual Disability
Brain Injuries
Cerebellum
Anemia
Fetus
Lymphocytes
Transplants
DNA
Wounds and Injuries

ASJC Scopus subject areas

  • General

Cite this

Griffin, W. S. T., Head, J. R., Woodward, D. J., & Carrol, C. (1978). Graft-versus-host disease impairs cerebellar growth [15]. Nature, 275(5678), 315-317. https://doi.org/10.1038/275315a0

Graft-versus-host disease impairs cerebellar growth [15]. / Griffin, W. S T; Head, J. R.; Woodward, D. J.; Carrol, C.

In: Nature, Vol. 275, No. 5678, 1978, p. 315-317.

Research output: Contribution to journalArticle

Griffin, WST, Head, JR, Woodward, DJ & Carrol, C 1978, 'Graft-versus-host disease impairs cerebellar growth [15]', Nature, vol. 275, no. 5678, pp. 315-317. https://doi.org/10.1038/275315a0
Griffin WST, Head JR, Woodward DJ, Carrol C. Graft-versus-host disease impairs cerebellar growth [15]. Nature. 1978;275(5678):315-317. https://doi.org/10.1038/275315a0
Griffin, W. S T ; Head, J. R. ; Woodward, D. J. ; Carrol, C. / Graft-versus-host disease impairs cerebellar growth [15]. In: Nature. 1978 ; Vol. 275, No. 5678. pp. 315-317.
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