Graft-vs-Host Disease as a Complication of Lung Transplantation

Douglas M. Smith, Edward D. Agura, Ken Ausloos, W. Steves Ring, Rana Domiati-Saad, Goran B. Klintmalm

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report a rare case of acute graft-vs-host disease (aGVHD) after a lung transplant. The patient presented with advanced disease manifested by skin rash, fever, diarrhea, liver dysfunction and severe pancytopenia. He went on to die of sepsis and multi-organ failure. aGVHD is a disease often confused with drug reactions or viral infection; therefore, it is important to have a high index of suspicion and to confirm the diagnosis early with tests for donor cell chimerism. Effective treatment is elusive but we are learning a great deal about the underlying mechanisms of this disease and hope to develop better treatment.

Original languageEnglish (US)
Pages (from-to)1175-1177
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume25
Issue number9
DOIs
StatePublished - Sep 2006

Fingerprint

Lung Transplantation
Graft vs Host Disease
Pancytopenia
Chimerism
Virus Diseases
Exanthema
Liver Diseases
Diarrhea
Sepsis
Fever
Tissue Donors
Learning
Transplants
Lung
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Smith, D. M., Agura, E. D., Ausloos, K., Ring, W. S., Domiati-Saad, R., & Klintmalm, G. B. (2006). Graft-vs-Host Disease as a Complication of Lung Transplantation. Journal of Heart and Lung Transplantation, 25(9), 1175-1177. https://doi.org/10.1016/j.healun.2006.05.008

Graft-vs-Host Disease as a Complication of Lung Transplantation. / Smith, Douglas M.; Agura, Edward D.; Ausloos, Ken; Ring, W. Steves; Domiati-Saad, Rana; Klintmalm, Goran B.

In: Journal of Heart and Lung Transplantation, Vol. 25, No. 9, 09.2006, p. 1175-1177.

Research output: Contribution to journalArticle

Smith, DM, Agura, ED, Ausloos, K, Ring, WS, Domiati-Saad, R & Klintmalm, GB 2006, 'Graft-vs-Host Disease as a Complication of Lung Transplantation', Journal of Heart and Lung Transplantation, vol. 25, no. 9, pp. 1175-1177. https://doi.org/10.1016/j.healun.2006.05.008
Smith, Douglas M. ; Agura, Edward D. ; Ausloos, Ken ; Ring, W. Steves ; Domiati-Saad, Rana ; Klintmalm, Goran B. / Graft-vs-Host Disease as a Complication of Lung Transplantation. In: Journal of Heart and Lung Transplantation. 2006 ; Vol. 25, No. 9. pp. 1175-1177.
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