Granular cell atypical fibroxanthoma: Case report and review of the literature

Natalie A. Wright, Crystal G. Thomas, Antoanella Calame, Clay J. Cockerell

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We present a case of granular cell atypical fibroxanthoma of the scalp. The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man. Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm. Many of the cells had large irregular nuclei and atypical mitotic figures were present. Immunohistochemical stains were positive for CD68 and procollagen 1 and negative for cytokeratin, HMB-45 and S-100 proteThe granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors. We discuss the differential diagnosis and review the previously reported cases of this rare variant of atypical fibroxanthoma.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalJournal of Cutaneous Pathology
Volume37
Issue number3
DOIs
StatePublished - Mar 1 2010

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Fingerprint Dive into the research topics of 'Granular cell atypical fibroxanthoma: Case report and review of the literature'. Together they form a unique fingerprint.

Cite this