Granulomatous hepatitis associated with carbamazepine therapy

Mack C. Mitchell; John K. Boitnott; Alberto Arregui; Willis C. Maddrey

doi:10.1016/0002-9343(81)90244-8

Granulomatous hepatitis associated with carbamazepine therapy

Mack C. Mitchell, John K. Boitnott, Alberto Arregui, Willis C. Maddrey

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Abstract

Granulomatous hepatitis developed in two patients while they were receiving carbamazepine (Tegretol^®). Both patients had evidence of hepatitis within one month of beginning the drug therapy and had a rapid and complete resolution once the agent was discontinued. In both, the liver biopsy contained granulomas in addition to acute portal inflammation. Carbamazepine should be added to the list of drugs causing granulomatous hepatitis.

Original language	English (US)
Pages (from-to)	733-735
Number of pages	3
Journal	The American Journal of Medicine
Volume	71
Issue number	4
DOIs	https://doi.org/10.1016/0002-9343(81)90244-8
State	Published - Oct 1981

ASJC Scopus subject areas

General Medicine

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10.1016/0002-9343(81)90244-8

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title = "Granulomatous hepatitis associated with carbamazepine therapy",

abstract = "Granulomatous hepatitis developed in two patients while they were receiving carbamazepine (Tegretol{\textregistered}). Both patients had evidence of hepatitis within one month of beginning the drug therapy and had a rapid and complete resolution once the agent was discontinued. In both, the liver biopsy contained granulomas in addition to acute portal inflammation. Carbamazepine should be added to the list of drugs causing granulomatous hepatitis.",

author = "Mitchell, {Mack C.} and Boitnott, {John K.} and Alberto Arregui and Maddrey, {Willis C.}",

year = "1981",

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AU - Mitchell, Mack C.

AU - Boitnott, John K.

AU - Arregui, Alberto

AU - Maddrey, Willis C.

PY - 1981/10

Y1 - 1981/10

N2 - Granulomatous hepatitis developed in two patients while they were receiving carbamazepine (Tegretol®). Both patients had evidence of hepatitis within one month of beginning the drug therapy and had a rapid and complete resolution once the agent was discontinued. In both, the liver biopsy contained granulomas in addition to acute portal inflammation. Carbamazepine should be added to the list of drugs causing granulomatous hepatitis.

AB - Granulomatous hepatitis developed in two patients while they were receiving carbamazepine (Tegretol®). Both patients had evidence of hepatitis within one month of beginning the drug therapy and had a rapid and complete resolution once the agent was discontinued. In both, the liver biopsy contained granulomas in addition to acute portal inflammation. Carbamazepine should be added to the list of drugs causing granulomatous hepatitis.

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Granulomatous hepatitis associated with carbamazepine therapy

Abstract

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