Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide

Sudershan R. Gondi, Asim K. Bera, Kenneth D. Westover

Research output: Contribution to journalArticle

Abstract

Synthetic methods used to generate substituted anilines and quinazolines, both privileged pharmacological structures, are cumbersome, hazardous or, in some cases, unavailable. We developed a straightforward method for making isatoic anhydride-8-amide from isatin-7-carboxylic acid as a tool to easily produce a range of quinazoline and substituted aniline derivatives using adaptable pH-sensitive cyclization chemistry. The approaches are inexpensive, simple, fast, efficient at room temperature and scalable, enabling the synthesis of both established and new quinazolines and also highly substituted anilines including cyano derivatives.

Original languageEnglish (US)
Article number14258
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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