Abstract
α,β-Unsaturated dioxolanones derived from mandelic acid smoothly add most Grignard reagents with good to excellent regio- and diastereoselectivities. The adducts are converted to chiral secondary alcohols by peroxidation at low temperature or to protected α-hydroxy aldehydes via ozonolysis.
Original language | English (US) |
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Pages (from-to) | 1421-1424 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 9 |
DOIs | |
State | Published - Feb 26 1996 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry