Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation

Emily B. Ballard, Jun Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Blastocyst complementation represents a powerful technique for interspecies organogenesis but is limited by low chimerism due to developmental incompatibilities. In this issue of Cell Stem Cell, Nishimura et al. (2021) circumvent early developmental barriers by disabling Igf1r in host embryos, conferring donor cells with a growth advantage from mid-gestation onward.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalCell Stem Cell
Volume28
Issue number1
DOIs
StatePublished - Jan 7 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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