Growth enhancement of transgenic mice expressing human insulin-like growth factor I

L. S. Mathews, Robert E Hammer, R. R. Behringer, A. J. D'Ercole, G. I. Bell, R. L. Brinster, R. D. Palmiter

Research output: Contribution to journalArticle

349 Citations (Scopus)

Abstract

A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.

Original languageEnglish (US)
Pages (from-to)2827-2833
Number of pages7
JournalEndocrinology
Volume123
Issue number6
StatePublished - 1988

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Insulin-Like Growth Factor I
Transgenic Mice
Growth
Metallothionein
Genes
Reference Values
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Mathews, L. S., Hammer, R. E., Behringer, R. R., D'Ercole, A. J., Bell, G. I., Brinster, R. L., & Palmiter, R. D. (1988). Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology, 123(6), 2827-2833.

Growth enhancement of transgenic mice expressing human insulin-like growth factor I. / Mathews, L. S.; Hammer, Robert E; Behringer, R. R.; D'Ercole, A. J.; Bell, G. I.; Brinster, R. L.; Palmiter, R. D.

In: Endocrinology, Vol. 123, No. 6, 1988, p. 2827-2833.

Research output: Contribution to journalArticle

Mathews, LS, Hammer, RE, Behringer, RR, D'Ercole, AJ, Bell, GI, Brinster, RL & Palmiter, RD 1988, 'Growth enhancement of transgenic mice expressing human insulin-like growth factor I', Endocrinology, vol. 123, no. 6, pp. 2827-2833.
Mathews LS, Hammer RE, Behringer RR, D'Ercole AJ, Bell GI, Brinster RL et al. Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology. 1988;123(6):2827-2833.
Mathews, L. S. ; Hammer, Robert E ; Behringer, R. R. ; D'Ercole, A. J. ; Bell, G. I. ; Brinster, R. L. ; Palmiter, R. D. / Growth enhancement of transgenic mice expressing human insulin-like growth factor I. In: Endocrinology. 1988 ; Vol. 123, No. 6. pp. 2827-2833.
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