Growth enhancement of transgenic mice expressing human insulin-like growth factor I

L. S. Mathews, Robert E Hammer, R. R. Behringer, A. J. D'Ercole, G. I. Bell, R. L. Brinster, R. D. Palmiter

Research output: Contribution to journalArticlepeer-review

356 Scopus citations

Abstract

A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.

Original languageEnglish (US)
Pages (from-to)2827-2833
Number of pages7
JournalEndocrinology
Volume123
Issue number6
DOIs
StatePublished - Dec 1988

ASJC Scopus subject areas

  • Endocrinology

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