Growth hormone - Aging and osteoporosis

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Abstract

Until recently, the use of growth hormone (GH) has been confined to the treatment of GH-deficient children. The advent of GH produced by recombinant DNA technology has increased the availability of GH. The increased availability of GH has made possible studies of the physiology and the possible therapeutic role of this hormone and its mediator insulin-like growth factor. One area where GH may play a therapeutic role is in the treatment of osteoporosis. This review will briefly summarize normal GH physiology and discuss age-related changes in GH and insulin-like growth factor 1 (IGF-1) axis and how they may relate to age-related physiologic changes. Evidence for and against a possible therapeutic role for GH/IGF-1 in the treatment of age-related (senile) osteoporosis will be discussed.

Original languageEnglish (US)
Pages (from-to)120-129
Number of pages10
JournalAmerican Journal of the Medical Sciences
Volume305
Issue number2
DOIs
StatePublished - Feb 17 1993

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Keywords

  • Aging
  • Growth hormone
  • Insulin-like growth factor
  • Osteoporosis

ASJC Scopus subject areas

  • Medicine(all)

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