Growth hormone attenuates the acute-phase response to thermal injury

Doraid Jarrar, Steven E. Wolf, Marc G. Jeschke, Roque J. Ramirez, Meelie DebRoy, Cora K. Ogle, John Papaconstaninou, David N. Herndon

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective: To determine the effects of growth hormone (GH) on the hepatic acute-phase response (APR) in a burned rat model. Setting: Laboratory. Material: Male Sprague-Dawley rats (weight, 300-350 g). Interventions: Rats underwent a 40% total body surface area burn injury and received GH or saline solution daily by subcutaneous injection. Unburned rats served as controls. Main Outcome Measures: Hepatic messenger RNA (mRNA) expression and serum levels of α1-acid glycoprotein and albumin were determined 2, 7, and 14 days after injury. Results: The serum α1-acid glycoprotein levels in GH-treated animals did not increase on days 2 and 7, whereas saline-treated animals showed a major increase. Hepatic mRNA expression increased dramatically on day 2 for burned groups; however, the mRNA pool levels of GH-treated animals showed a faster rate of decline to control levels on days 7 and 14. The albumin mRNA pool levels of GH-treated and control animals did not show significant differences, whereas the negative APR, as indicated by loss of albumin mRNA, was more pronounced on day 7 in the saline-treated animals. By day 14, mRNA levels were comparable in all 3 groups. Conclusion: Growth hormone attenuated the positive APR, as indicated by a decrease in α1-acid glycoprotein expression and production, and prevented the negative APR, as seen by an absence of a decline of albumin mRNA pool levels and serum concentration. We conclude that the beneficial effects of GH on thermal injury may be due in part to a modification of the APR.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalArchives of Surgery
Volume132
Issue number11
StatePublished - Nov 1997

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Acute-Phase Reaction
Growth Hormone
Hot Temperature
Messenger RNA
Wounds and Injuries
Albumins
Glycoproteins
Acids
Liver
Serum
Body Surface Area
Subcutaneous Injections
Sodium Chloride
Sprague Dawley Rats
Outcome Assessment (Health Care)
Weights and Measures

ASJC Scopus subject areas

  • Surgery

Cite this

Jarrar, D., Wolf, S. E., Jeschke, M. G., Ramirez, R. J., DebRoy, M., Ogle, C. K., ... Herndon, D. N. (1997). Growth hormone attenuates the acute-phase response to thermal injury. Archives of Surgery, 132(11), 1171-1176.

Growth hormone attenuates the acute-phase response to thermal injury. / Jarrar, Doraid; Wolf, Steven E.; Jeschke, Marc G.; Ramirez, Roque J.; DebRoy, Meelie; Ogle, Cora K.; Papaconstaninou, John; Herndon, David N.

In: Archives of Surgery, Vol. 132, No. 11, 11.1997, p. 1171-1176.

Research output: Contribution to journalArticle

Jarrar, D, Wolf, SE, Jeschke, MG, Ramirez, RJ, DebRoy, M, Ogle, CK, Papaconstaninou, J & Herndon, DN 1997, 'Growth hormone attenuates the acute-phase response to thermal injury', Archives of Surgery, vol. 132, no. 11, pp. 1171-1176.
Jarrar D, Wolf SE, Jeschke MG, Ramirez RJ, DebRoy M, Ogle CK et al. Growth hormone attenuates the acute-phase response to thermal injury. Archives of Surgery. 1997 Nov;132(11):1171-1176.
Jarrar, Doraid ; Wolf, Steven E. ; Jeschke, Marc G. ; Ramirez, Roque J. ; DebRoy, Meelie ; Ogle, Cora K. ; Papaconstaninou, John ; Herndon, David N. / Growth hormone attenuates the acute-phase response to thermal injury. In: Archives of Surgery. 1997 ; Vol. 132, No. 11. pp. 1171-1176.
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