Growth hormone response to baclofen: A comparison of 10-mg and 20-mg doses in healthy men

Lori L. Davis, Madhukar Trivedi, Gerald L. Kramer, A. John Rush, Paul J. Orsulak, Linda Akers, Frederick Petty

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8 Scopus citations

Abstract

Growth hormone (GH) response and baclofen levels were measured in seven healthy adult men following a 10-mg and a 20-mg dose of oral baclofen (γ-aminobutyric acid, agonist) to determine the preferred dose in baclofen challenge studies. Multivariate analysis of variance (ANOVA) with repeated measures revealed no differences between the doses. However, when a univariate ANOVA with repeated measures was performed for each dose, the 10-mg dose showed no significant GH response over time, whereas the 20-mg dose showed a significant GH response over time. The average ΔGH (change in GH from baseline) was 7.84 ng/ml (SD = 10.17) for the 10-mg dose and 3.34 ng/ml (SD = 3.64) for the 20-mg dose. The variability in the ΔGH response to the 10-mg dose was significantly greater than the response to the 20-mg dose of baclofen. This variance in GH response was not explained by the differences in serum baclofen levels. Thus, a 20-mg baclofen dose appears to be preferable to a 10 mg-dose in baclofen challenge studies.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalPsychiatry Research
Volume60
Issue number1
DOIs
Publication statusPublished - Feb 28 1996

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Keywords

  • Gamma-aminobutyric acid
  • Hypothalamus
  • Neuroendocrinology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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