Growth hormone response to the GABA(B) agonist baclofen in major depressive disorder

Lori L. Davis; Madhukar Trivedi; Amy Choate; Gerald L. Kramer; Frederick Petty

doi:10.1016/S0306-4530(96)00048-0

Growth hormone response to the GABA(B) agonist baclofen in major depressive disorder

Lori L. Davis, Madhukar Trivedi, Amy Choate, Gerald L. Kramer, Frederick Petty

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Growth hormone (GH) response to the γ-aminobutyric acid B receptor agonist, baclofen, was measured in 16 male patients with major depressive disorder and in 16 age-matched healthy male controls. No significant differences were found in the GH response to baclofen between the depressed patients and controls. On repeat testing, the GH response to baclofen showed significant retest reliability in both groups. There was no significant correlation between serum baclofen levels and the GH response to baclofen. Age significantly correlated with GH response, with older subjects having lower GH response to baclofen. These data do not suggest that a blunted GH response to baclofen represents a specific neuroendocrine feature of major depression.

Original language	English (US)
Pages (from-to)	129-140
Number of pages	12
Journal	Psychoneuroendocrinology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/S0306-4530(96)00048-0
State	Published - Apr 1997

Keywords

Baclofen
GABA-B receptor
Growth hormone
Major depression
Neuroendocrine
γ-aminobutyric acid

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

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title = "Growth hormone response to the GABA(B) agonist baclofen in major depressive disorder",

abstract = "Growth hormone (GH) response to the γ-aminobutyric acid B receptor agonist, baclofen, was measured in 16 male patients with major depressive disorder and in 16 age-matched healthy male controls. No significant differences were found in the GH response to baclofen between the depressed patients and controls. On repeat testing, the GH response to baclofen showed significant retest reliability in both groups. There was no significant correlation between serum baclofen levels and the GH response to baclofen. Age significantly correlated with GH response, with older subjects having lower GH response to baclofen. These data do not suggest that a blunted GH response to baclofen represents a specific neuroendocrine feature of major depression.",

keywords = "Baclofen, GABA-B receptor, Growth hormone, Major depression, Neuroendocrine, γ-aminobutyric acid",

author = "Davis, {Lori L.} and Madhukar Trivedi and Amy Choate and Kramer, {Gerald L.} and Frederick Petty",

note = "Funding Information: Acknowledgements: The authors would like to thank Kenneth Z. Althsuler, MD, Stanton Sharp Distinguished Chair and Chairman, for his generous support and encouragement; A. John Rush, MD for his expert supervision; and Kenneth Shewmake for his laboratory assistance. This study was supported by a Research Advisory Group grant from the Department of Veterans Affairs, the University of Texas Southwestern Medical School General Clinical Research Center (M01-RR00633), and the John Schermerhorn Fund.",

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doi = "10.1016/S0306-4530(96)00048-0",

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AU - Trivedi, Madhukar

AU - Choate, Amy

AU - Kramer, Gerald L.

AU - Petty, Frederick

N1 - Funding Information: Acknowledgements: The authors would like to thank Kenneth Z. Althsuler, MD, Stanton Sharp Distinguished Chair and Chairman, for his generous support and encouragement; A. John Rush, MD for his expert supervision; and Kenneth Shewmake for his laboratory assistance. This study was supported by a Research Advisory Group grant from the Department of Veterans Affairs, the University of Texas Southwestern Medical School General Clinical Research Center (M01-RR00633), and the John Schermerhorn Fund.

PY - 1997/4

Y1 - 1997/4

N2 - Growth hormone (GH) response to the γ-aminobutyric acid B receptor agonist, baclofen, was measured in 16 male patients with major depressive disorder and in 16 age-matched healthy male controls. No significant differences were found in the GH response to baclofen between the depressed patients and controls. On repeat testing, the GH response to baclofen showed significant retest reliability in both groups. There was no significant correlation between serum baclofen levels and the GH response to baclofen. Age significantly correlated with GH response, with older subjects having lower GH response to baclofen. These data do not suggest that a blunted GH response to baclofen represents a specific neuroendocrine feature of major depression.

AB - Growth hormone (GH) response to the γ-aminobutyric acid B receptor agonist, baclofen, was measured in 16 male patients with major depressive disorder and in 16 age-matched healthy male controls. No significant differences were found in the GH response to baclofen between the depressed patients and controls. On repeat testing, the GH response to baclofen showed significant retest reliability in both groups. There was no significant correlation between serum baclofen levels and the GH response to baclofen. Age significantly correlated with GH response, with older subjects having lower GH response to baclofen. These data do not suggest that a blunted GH response to baclofen represents a specific neuroendocrine feature of major depression.

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KW - GABA-B receptor

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KW - Neuroendocrine

KW - γ-aminobutyric acid

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Growth hormone response to the GABA(B) agonist baclofen in major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

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