Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth

Cristina T. Navarrete, Shahnaz Duara, Lisa A. Wrage, Marie G. Gantz, Waldemar A. Carlo, Michele C. Walsh, Wade Rich, Nancy S. Newman, Abhik Das, Kurt Schibler, Anthony J. Piazza, Brenda B. Poindexter, Seetha Shankaran, Pablo J. Sánchez, Brenda H. Morris, Ivan D. Frantz, Krisa P. Van Meurs, C. Michael Cotten, Richard A. Ehrenkranz, Edward F. Bell & 188 others Kristi L. Watterberg, Rosemary D. Higgins, Abhik Das, Marie Gantz, Alan H. Jobe, Michael S. Caplan, Avroy A. Fanaroff, Deanne E. Wilson-Costello, Bonnie S. Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G. Friedman, Gulgun Yalcinkaya, Edward F. Donovan, Vivek Narendran, Kimberly Yolton, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L. Mincey, Jody Hessling, Teresa L. Gratton, Ronald N. Goldberg, Ricki F. Goldstein, Patricia Ashley, Kathy J. Auten, Kimberley A. Fisher, Katherine A. Foy, Sharon F. Freedman, Kathryn E. Gustafson, Melody B. Lohmeyer, William F. Malcolm, David K. Wallace, Barbara J. Stoll, Ira Adams-Chapman, Susie Buchter, David P. Carlton, Sheena Carter, Sobha Fritz, Ellen C. Hale, Amy K. Hutchinson, Maureen Mulligan LaRossa, Gloria V. Smikle, Stephanie Wilson Archer, Anna M. Dusick, James A. Lemons, Gary J. Myers, Leslie D. Wilson, Faithe Hamer, Ann B. Cook, Dianne E. Herron, Carolyn Lytle, Heike M. Minnich, Mary Anne Berberich, Carol J. Blaisdell, Dorothy B. Gail, James P. Kiley, W. Kenneth Poole, Jamie E. Newman, Betty K. Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, James W. Pickett, Dennis Wallace, Kristin M. Zaterka-Baxter, David K. Stevenson, Susan R. Hintz, M. Bethany Ball, Barbara Bentley, Elizabeth F. Bruno, Alexis S. Davis, Maria Elena DeAnda, Anne M. DeBattista, Lynne C. Huffman, Jean G. Kohn, Melinda S. Proud, Renee P. Pyle, Nicholas John, Hali E. Weiss, John M. Fiascone, Elisabeth C. McGowan, Anne Furey, Brenda L. MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V. Collins, Shirley S. Cosby, Vivien A. Phillips, Kirstin J. Bailey, Fred J. Biasini, Maria Hopkins, Kristen C. Johnston, Sara Krzywanski, Kathleen G. Nelson, Cryshelle S. Patterson, Richard V. Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, John A. Widness, Michael J. Acarregui, Jonathan M. Klein, Tarah T. Colaizy, Karen J. Johnson, Diane L. Eastman, Charles R. Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N. Diaz, Silvia M. Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Helina Pierre, Arielle Rigaud, Alexandra Stroerger, Robin K. Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Luc Brion, Charles R. Rosenfeld, Walid A. Salhab, Roy J. Heyne, Sally S. Adams, James Allen, Lijun Chen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T. Heyne, Jackie Hickman, Melissa H. Lepps, Linda A. Madden, Nancy A. Miller, Janet S. Morgan, Araceli Solis, Lizette E. Torres, Catherine Twell Boatman, Diana M. Vasil, Kathleen A. Kennedy, Jon E. Tyson, Esther G. Akpa, Nora I. Alaniz, Susan Dieterich, Patricia W. Evans, Charles Green, Beverly Foley Harris, Margarita Jiminez, Anna E. Lis, Karen Martin, Sarah Martin, Georgia E. McDavid, Brenda H. Morris, M. Layne Poundstone, Stacey Reddoch, Saba Siddiki, Maegan C. Simmons, Patti L. Pierce Tate, Sharon L. Wright, Beena G. Sood, Athina Pappas, Rebecca Bara, Elizabeth Billian, Laura A. Goldston, Mary Johnson, Vineet Bhandari, Harris C. Jacobs, Pat Cervone, Patricia Gettner, Monica Konstantino, Jo Ann Poulsen, Janet Taft, Christine G. Butler, Nancy Close, Walter Gilliam, Sheila Greisman, Elaine Romano, Joanne Williams

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. Study design We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression. Results Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups. Conclusion Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.

Original languageEnglish (US)
Pages (from-to)62-68.e4
JournalJournal of Pediatrics
Volume176
DOIs
StatePublished - Sep 1 2016

Fingerprint

Premature Infants
Parturition
Oxygen
Growth
Birth Weight
Surface-Active Agents
Linear Models
Pressure
Weights and Measures

Keywords

  • ELBW growth
  • oxygen saturation target

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Navarrete, C. T., Duara, S., Wrage, L. A., Gantz, M. G., Carlo, W. A., Walsh, M. C., ... Williams, J. (2016). Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. Journal of Pediatrics, 176, 62-68.e4. https://doi.org/10.1016/j.jpeds.2016.05.070

Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. / Navarrete, Cristina T.; Duara, Shahnaz; Wrage, Lisa A.; Gantz, Marie G.; Carlo, Waldemar A.; Walsh, Michele C.; Rich, Wade; Newman, Nancy S.; Das, Abhik; Schibler, Kurt; Piazza, Anthony J.; Poindexter, Brenda B.; Shankaran, Seetha; Sánchez, Pablo J.; Morris, Brenda H.; Frantz, Ivan D.; Van Meurs, Krisa P.; Cotten, C. Michael; Ehrenkranz, Richard A.; Bell, Edward F.; Watterberg, Kristi L.; Higgins, Rosemary D.; Das, Abhik; Gantz, Marie; Jobe, Alan H.; Caplan, Michael S.; Fanaroff, Avroy A.; Wilson-Costello, Deanne E.; Siner, Bonnie S.; Zadell, Arlene; DiFiore, Julie; Bhola, Monika; Friedman, Harriet G.; Yalcinkaya, Gulgun; Donovan, Edward F.; Narendran, Vivek; Yolton, Kimberly; Bridges, Kate; Alexander, Barbara; Grisby, Cathy; Mersmann, Marcia Worley; Mincey, Holly L.; Hessling, Jody; Gratton, Teresa L.; Goldberg, Ronald N.; Goldstein, Ricki F.; Ashley, Patricia; Auten, Kathy J.; Fisher, Kimberley A.; Foy, Katherine A.; Freedman, Sharon F.; Gustafson, Kathryn E.; Lohmeyer, Melody B.; Malcolm, William F.; Wallace, David K.; Stoll, Barbara J.; Adams-Chapman, Ira; Buchter, Susie; Carlton, David P.; Carter, Sheena; Fritz, Sobha; Hale, Ellen C.; Hutchinson, Amy K.; LaRossa, Maureen Mulligan; Smikle, Gloria V.; Archer, Stephanie Wilson; Dusick, Anna M.; Lemons, James A.; Myers, Gary J.; Wilson, Leslie D.; Hamer, Faithe; Cook, Ann B.; Herron, Dianne E.; Lytle, Carolyn; Minnich, Heike M.; Berberich, Mary Anne; Blaisdell, Carol J.; Gail, Dorothy B.; Kiley, James P.; Poole, W. Kenneth; Newman, Jamie E.; Hastings, Betty K.; O'Donnell Auman, Jeanette; Huitema, Carolyn Petrie; Pickett, James W.; Wallace, Dennis; Zaterka-Baxter, Kristin M.; Stevenson, David K.; Hintz, Susan R.; Ball, M. Bethany; Bentley, Barbara; Bruno, Elizabeth F.; Davis, Alexis S.; DeAnda, Maria Elena; DeBattista, Anne M.; Huffman, Lynne C.; Kohn, Jean G.; Proud, Melinda S.; Pyle, Renee P.; John, Nicholas; Weiss, Hali E.; Fiascone, John M.; McGowan, Elisabeth C.; Furey, Anne; MacKinnon, Brenda L.; Nylen, Ellen; Brussa, Ana; Sibley, Cecelia; Ambalavanan, Namasivayam; Peralta-Carcelen, Myriam; Collins, Monica V.; Cosby, Shirley S.; Phillips, Vivien A.; Bailey, Kirstin J.; Biasini, Fred J.; Hopkins, Maria; Johnston, Kristen C.; Krzywanski, Sara; Nelson, Kathleen G.; Patterson, Cryshelle S.; Rector, Richard V.; Rodriguez, Leslie; Soong, Amanda; Whitley, Sally; York, Sheree; Widness, John A.; Acarregui, Michael J.; Klein, Jonathan M.; Colaizy, Tarah T.; Johnson, Karen J.; Eastman, Diane L.; Bauer, Charles R.; Everett-Thomas, Ruth; Calejo, Maria; Diaz, Alexis N.; Frade Eguaras, Silvia M.; Garcia, Andrea; Hamlin-Smith, Kasey; Berkowits, Michelle Harwood; Hiriart-Fajardo, Sylvia; Pierre, Helina; Rigaud, Arielle; Stroerger, Alexandra; Ohls, Robin K.; Fuller, Janell; Rohr, Julie; Lacy, Conra Backstrom; Lowe, Jean; Montman, Rebecca; Brion, Luc; Rosenfeld, Charles R.; Salhab, Walid A.; Heyne, Roy J.; Adams, Sally S.; Allen, James; Chen, Lijun; Grau, Laura; Guzman, Alicia; Hensley, Gaynelle; Heyne, Elizabeth T.; Hickman, Jackie; Lepps, Melissa H.; Madden, Linda A.; Miller, Nancy A.; Morgan, Janet S.; Solis, Araceli; Torres, Lizette E.; Boatman, Catherine Twell; Vasil, Diana M.; Kennedy, Kathleen A.; Tyson, Jon E.; Akpa, Esther G.; Alaniz, Nora I.; Dieterich, Susan; Evans, Patricia W.; Green, Charles; Harris, Beverly Foley; Jiminez, Margarita; Lis, Anna E.; Martin, Karen; Martin, Sarah; McDavid, Georgia E.; Morris, Brenda H.; Poundstone, M. Layne; Reddoch, Stacey; Siddiki, Saba; Simmons, Maegan C.; Pierce Tate, Patti L.; Wright, Sharon L.; Sood, Beena G.; Pappas, Athina; Bara, Rebecca; Billian, Elizabeth; Goldston, Laura A.; Johnson, Mary; Bhandari, Vineet; Jacobs, Harris C.; Cervone, Pat; Gettner, Patricia; Konstantino, Monica; Poulsen, Jo Ann; Taft, Janet; Butler, Christine G.; Close, Nancy; Gilliam, Walter; Greisman, Sheila; Romano, Elaine; Williams, Joanne.

In: Journal of Pediatrics, Vol. 176, 01.09.2016, p. 62-68.e4.

Research output: Contribution to journalArticle

Navarrete, CT, Duara, S, Wrage, LA, Gantz, MG, Carlo, WA, Walsh, MC, Rich, W, Newman, NS, Das, A, Schibler, K, Piazza, AJ, Poindexter, BB, Shankaran, S, Sánchez, PJ, Morris, BH, Frantz, ID, Van Meurs, KP, Cotten, CM, Ehrenkranz, RA, Bell, EF, Watterberg, KL, Higgins, RD, Das, A, Gantz, M, Jobe, AH, Caplan, MS, Fanaroff, AA, Wilson-Costello, DE, Siner, BS, Zadell, A, DiFiore, J, Bhola, M, Friedman, HG, Yalcinkaya, G, Donovan, EF, Narendran, V, Yolton, K, Bridges, K, Alexander, B, Grisby, C, Mersmann, MW, Mincey, HL, Hessling, J, Gratton, TL, Goldberg, RN, Goldstein, RF, Ashley, P, Auten, KJ, Fisher, KA, Foy, KA, Freedman, SF, Gustafson, KE, Lohmeyer, MB, Malcolm, WF, Wallace, DK, Stoll, BJ, Adams-Chapman, I, Buchter, S, Carlton, DP, Carter, S, Fritz, S, Hale, EC, Hutchinson, AK, LaRossa, MM, Smikle, GV, Archer, SW, Dusick, AM, Lemons, JA, Myers, GJ, Wilson, LD, Hamer, F, Cook, AB, Herron, DE, Lytle, C, Minnich, HM, Berberich, MA, Blaisdell, CJ, Gail, DB, Kiley, JP, Poole, WK, Newman, JE, Hastings, BK, O'Donnell Auman, J, Huitema, CP, Pickett, JW, Wallace, D, Zaterka-Baxter, KM, Stevenson, DK, Hintz, SR, Ball, MB, Bentley, B, Bruno, EF, Davis, AS, DeAnda, ME, DeBattista, AM, Huffman, LC, Kohn, JG, Proud, MS, Pyle, RP, John, N, Weiss, HE, Fiascone, JM, McGowan, EC, Furey, A, MacKinnon, BL, Nylen, E, Brussa, A, Sibley, C, Ambalavanan, N, Peralta-Carcelen, M, Collins, MV, Cosby, SS, Phillips, VA, Bailey, KJ, Biasini, FJ, Hopkins, M, Johnston, KC, Krzywanski, S, Nelson, KG, Patterson, CS, Rector, RV, Rodriguez, L, Soong, A, Whitley, S, York, S, Widness, JA, Acarregui, MJ, Klein, JM, Colaizy, TT, Johnson, KJ, Eastman, DL, Bauer, CR, Everett-Thomas, R, Calejo, M, Diaz, AN, Frade Eguaras, SM, Garcia, A, Hamlin-Smith, K, Berkowits, MH, Hiriart-Fajardo, S, Pierre, H, Rigaud, A, Stroerger, A, Ohls, RK, Fuller, J, Rohr, J, Lacy, CB, Lowe, J, Montman, R, Brion, L, Rosenfeld, CR, Salhab, WA, Heyne, RJ, Adams, SS, Allen, J, Chen, L, Grau, L, Guzman, A, Hensley, G, Heyne, ET, Hickman, J, Lepps, MH, Madden, LA, Miller, NA, Morgan, JS, Solis, A, Torres, LE, Boatman, CT, Vasil, DM, Kennedy, KA, Tyson, JE, Akpa, EG, Alaniz, NI, Dieterich, S, Evans, PW, Green, C, Harris, BF, Jiminez, M, Lis, AE, Martin, K, Martin, S, McDavid, GE, Morris, BH, Poundstone, ML, Reddoch, S, Siddiki, S, Simmons, MC, Pierce Tate, PL, Wright, SL, Sood, BG, Pappas, A, Bara, R, Billian, E, Goldston, LA, Johnson, M, Bhandari, V, Jacobs, HC, Cervone, P, Gettner, P, Konstantino, M, Poulsen, JA, Taft, J, Butler, CG, Close, N, Gilliam, W, Greisman, S, Romano, E & Williams, J 2016, 'Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth', Journal of Pediatrics, vol. 176, pp. 62-68.e4. https://doi.org/10.1016/j.jpeds.2016.05.070
Navarrete, Cristina T. ; Duara, Shahnaz ; Wrage, Lisa A. ; Gantz, Marie G. ; Carlo, Waldemar A. ; Walsh, Michele C. ; Rich, Wade ; Newman, Nancy S. ; Das, Abhik ; Schibler, Kurt ; Piazza, Anthony J. ; Poindexter, Brenda B. ; Shankaran, Seetha ; Sánchez, Pablo J. ; Morris, Brenda H. ; Frantz, Ivan D. ; Van Meurs, Krisa P. ; Cotten, C. Michael ; Ehrenkranz, Richard A. ; Bell, Edward F. ; Watterberg, Kristi L. ; Higgins, Rosemary D. ; Das, Abhik ; Gantz, Marie ; Jobe, Alan H. ; Caplan, Michael S. ; Fanaroff, Avroy A. ; Wilson-Costello, Deanne E. ; Siner, Bonnie S. ; Zadell, Arlene ; DiFiore, Julie ; Bhola, Monika ; Friedman, Harriet G. ; Yalcinkaya, Gulgun ; Donovan, Edward F. ; Narendran, Vivek ; Yolton, Kimberly ; Bridges, Kate ; Alexander, Barbara ; Grisby, Cathy ; Mersmann, Marcia Worley ; Mincey, Holly L. ; Hessling, Jody ; Gratton, Teresa L. ; Goldberg, Ronald N. ; Goldstein, Ricki F. ; Ashley, Patricia ; Auten, Kathy J. ; Fisher, Kimberley A. ; Foy, Katherine A. ; Freedman, Sharon F. ; Gustafson, Kathryn E. ; Lohmeyer, Melody B. ; Malcolm, William F. ; Wallace, David K. ; Stoll, Barbara J. ; Adams-Chapman, Ira ; Buchter, Susie ; Carlton, David P. ; Carter, Sheena ; Fritz, Sobha ; Hale, Ellen C. ; Hutchinson, Amy K. ; LaRossa, Maureen Mulligan ; Smikle, Gloria V. ; Archer, Stephanie Wilson ; Dusick, Anna M. ; Lemons, James A. ; Myers, Gary J. ; Wilson, Leslie D. ; Hamer, Faithe ; Cook, Ann B. ; Herron, Dianne E. ; Lytle, Carolyn ; Minnich, Heike M. ; Berberich, Mary Anne ; Blaisdell, Carol J. ; Gail, Dorothy B. ; Kiley, James P. ; Poole, W. Kenneth ; Newman, Jamie E. ; Hastings, Betty K. ; O'Donnell Auman, Jeanette ; Huitema, Carolyn Petrie ; Pickett, James W. ; Wallace, Dennis ; Zaterka-Baxter, Kristin M. ; Stevenson, David K. ; Hintz, Susan R. ; Ball, M. Bethany ; Bentley, Barbara ; Bruno, Elizabeth F. ; Davis, Alexis S. ; DeAnda, Maria Elena ; DeBattista, Anne M. ; Huffman, Lynne C. ; Kohn, Jean G. ; Proud, Melinda S. ; Pyle, Renee P. ; John, Nicholas ; Weiss, Hali E. ; Fiascone, John M. ; McGowan, Elisabeth C. ; Furey, Anne ; MacKinnon, Brenda L. ; Nylen, Ellen ; Brussa, Ana ; Sibley, Cecelia ; Ambalavanan, Namasivayam ; Peralta-Carcelen, Myriam ; Collins, Monica V. ; Cosby, Shirley S. ; Phillips, Vivien A. ; Bailey, Kirstin J. ; Biasini, Fred J. ; Hopkins, Maria ; Johnston, Kristen C. ; Krzywanski, Sara ; Nelson, Kathleen G. ; Patterson, Cryshelle S. ; Rector, Richard V. ; Rodriguez, Leslie ; Soong, Amanda ; Whitley, Sally ; York, Sheree ; Widness, John A. ; Acarregui, Michael J. ; Klein, Jonathan M. ; Colaizy, Tarah T. ; Johnson, Karen J. ; Eastman, Diane L. ; Bauer, Charles R. ; Everett-Thomas, Ruth ; Calejo, Maria ; Diaz, Alexis N. ; Frade Eguaras, Silvia M. ; Garcia, Andrea ; Hamlin-Smith, Kasey ; Berkowits, Michelle Harwood ; Hiriart-Fajardo, Sylvia ; Pierre, Helina ; Rigaud, Arielle ; Stroerger, Alexandra ; Ohls, Robin K. ; Fuller, Janell ; Rohr, Julie ; Lacy, Conra Backstrom ; Lowe, Jean ; Montman, Rebecca ; Brion, Luc ; Rosenfeld, Charles R. ; Salhab, Walid A. ; Heyne, Roy J. ; Adams, Sally S. ; Allen, James ; Chen, Lijun ; Grau, Laura ; Guzman, Alicia ; Hensley, Gaynelle ; Heyne, Elizabeth T. ; Hickman, Jackie ; Lepps, Melissa H. ; Madden, Linda A. ; Miller, Nancy A. ; Morgan, Janet S. ; Solis, Araceli ; Torres, Lizette E. ; Boatman, Catherine Twell ; Vasil, Diana M. ; Kennedy, Kathleen A. ; Tyson, Jon E. ; Akpa, Esther G. ; Alaniz, Nora I. ; Dieterich, Susan ; Evans, Patricia W. ; Green, Charles ; Harris, Beverly Foley ; Jiminez, Margarita ; Lis, Anna E. ; Martin, Karen ; Martin, Sarah ; McDavid, Georgia E. ; Morris, Brenda H. ; Poundstone, M. Layne ; Reddoch, Stacey ; Siddiki, Saba ; Simmons, Maegan C. ; Pierce Tate, Patti L. ; Wright, Sharon L. ; Sood, Beena G. ; Pappas, Athina ; Bara, Rebecca ; Billian, Elizabeth ; Goldston, Laura A. ; Johnson, Mary ; Bhandari, Vineet ; Jacobs, Harris C. ; Cervone, Pat ; Gettner, Patricia ; Konstantino, Monica ; Poulsen, Jo Ann ; Taft, Janet ; Butler, Christine G. ; Close, Nancy ; Gilliam, Walter ; Greisman, Sheila ; Romano, Elaine ; Williams, Joanne. / Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. In: Journal of Pediatrics. 2016 ; Vol. 176. pp. 62-68.e4.
@article{00f9614279fe4fbab71d12e0403a10b7,
title = "Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth",
abstract = "Objective To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. Study design We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85{\%}-89{\%}, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91{\%}-95{\%}, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression. Results Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups. Conclusion Targeting different oxygen saturation ranges between 85{\%} and 95{\%} from birth did not impact growth velocity or reduce growth failure in preterm infants.",
keywords = "ELBW growth, oxygen saturation target",
author = "Navarrete, {Cristina T.} and Shahnaz Duara and Wrage, {Lisa A.} and Gantz, {Marie G.} and Carlo, {Waldemar A.} and Walsh, {Michele C.} and Wade Rich and Newman, {Nancy S.} and Abhik Das and Kurt Schibler and Piazza, {Anthony J.} and Poindexter, {Brenda B.} and Seetha Shankaran and S{\'a}nchez, {Pablo J.} and Morris, {Brenda H.} and Frantz, {Ivan D.} and {Van Meurs}, {Krisa P.} and Cotten, {C. Michael} and Ehrenkranz, {Richard A.} and Bell, {Edward F.} and Watterberg, {Kristi L.} and Higgins, {Rosemary D.} and Abhik Das and Marie Gantz and Jobe, {Alan H.} and Caplan, {Michael S.} and Fanaroff, {Avroy A.} and Wilson-Costello, {Deanne E.} and Siner, {Bonnie S.} and Arlene Zadell and Julie DiFiore and Monika Bhola and Friedman, {Harriet G.} and Gulgun Yalcinkaya and Donovan, {Edward F.} and Vivek Narendran and Kimberly Yolton and Kate Bridges and Barbara Alexander and Cathy Grisby and Mersmann, {Marcia Worley} and Mincey, {Holly L.} and Jody Hessling and Gratton, {Teresa L.} and Goldberg, {Ronald N.} and Goldstein, {Ricki F.} and Patricia Ashley and Auten, {Kathy J.} and Fisher, {Kimberley A.} and Foy, {Katherine A.} and Freedman, {Sharon F.} and Gustafson, {Kathryn E.} and Lohmeyer, {Melody B.} and Malcolm, {William F.} and Wallace, {David K.} and Stoll, {Barbara J.} and Ira Adams-Chapman and Susie Buchter and Carlton, {David P.} and Sheena Carter and Sobha Fritz and Hale, {Ellen C.} and Hutchinson, {Amy K.} and LaRossa, {Maureen Mulligan} and Smikle, {Gloria V.} and Archer, {Stephanie Wilson} and Dusick, {Anna M.} and Lemons, {James A.} and Myers, {Gary J.} and Wilson, {Leslie D.} and Faithe Hamer and Cook, {Ann B.} and Herron, {Dianne E.} and Carolyn Lytle and Minnich, {Heike M.} and Berberich, {Mary Anne} and Blaisdell, {Carol J.} and Gail, {Dorothy B.} and Kiley, {James P.} and Poole, {W. Kenneth} and Newman, {Jamie E.} and Hastings, {Betty K.} and {O'Donnell Auman}, Jeanette and Huitema, {Carolyn Petrie} and Pickett, {James W.} and Dennis Wallace and Zaterka-Baxter, {Kristin M.} and Stevenson, {David K.} and Hintz, {Susan R.} and Ball, {M. Bethany} and Barbara Bentley and Bruno, {Elizabeth F.} and Davis, {Alexis S.} and DeAnda, {Maria Elena} and DeBattista, {Anne M.} and Huffman, {Lynne C.} and Kohn, {Jean G.} and Proud, {Melinda S.} and Pyle, {Renee P.} and Nicholas John and Weiss, {Hali E.} and Fiascone, {John M.} and McGowan, {Elisabeth C.} and Anne Furey and MacKinnon, {Brenda L.} and Ellen Nylen and Ana Brussa and Cecelia Sibley and Namasivayam Ambalavanan and Myriam Peralta-Carcelen and Collins, {Monica V.} and Cosby, {Shirley S.} and Phillips, {Vivien A.} and Bailey, {Kirstin J.} and Biasini, {Fred J.} and Maria Hopkins and Johnston, {Kristen C.} and Sara Krzywanski and Nelson, {Kathleen G.} and Patterson, {Cryshelle S.} and Rector, {Richard V.} and Leslie Rodriguez and Amanda Soong and Sally Whitley and Sheree York and Widness, {John A.} and Acarregui, {Michael J.} and Klein, {Jonathan M.} and Colaizy, {Tarah T.} and Johnson, {Karen J.} and Eastman, {Diane L.} and Bauer, {Charles R.} and Ruth Everett-Thomas and Maria Calejo and Diaz, {Alexis N.} and {Frade Eguaras}, {Silvia M.} and Andrea Garcia and Kasey Hamlin-Smith and Berkowits, {Michelle Harwood} and Sylvia Hiriart-Fajardo and Helina Pierre and Arielle Rigaud and Alexandra Stroerger and Ohls, {Robin K.} and Janell Fuller and Julie Rohr and Lacy, {Conra Backstrom} and Jean Lowe and Rebecca Montman and Luc Brion and Rosenfeld, {Charles R.} and Salhab, {Walid A.} and Heyne, {Roy J.} and Adams, {Sally S.} and James Allen and Lijun Chen and Laura Grau and Alicia Guzman and Gaynelle Hensley and Heyne, {Elizabeth T.} and Jackie Hickman and Lepps, {Melissa H.} and Madden, {Linda A.} and Miller, {Nancy A.} and Morgan, {Janet S.} and Araceli Solis and Torres, {Lizette E.} and Boatman, {Catherine Twell} and Vasil, {Diana M.} and Kennedy, {Kathleen A.} and Tyson, {Jon E.} and Akpa, {Esther G.} and Alaniz, {Nora I.} and Susan Dieterich and Evans, {Patricia W.} and Charles Green and Harris, {Beverly Foley} and Margarita Jiminez and Lis, {Anna E.} and Karen Martin and Sarah Martin and McDavid, {Georgia E.} and Morris, {Brenda H.} and Poundstone, {M. Layne} and Stacey Reddoch and Saba Siddiki and Simmons, {Maegan C.} and {Pierce Tate}, {Patti L.} and Wright, {Sharon L.} and Sood, {Beena G.} and Athina Pappas and Rebecca Bara and Elizabeth Billian and Goldston, {Laura A.} and Mary Johnson and Vineet Bhandari and Jacobs, {Harris C.} and Pat Cervone and Patricia Gettner and Monica Konstantino and Poulsen, {Jo Ann} and Janet Taft and Butler, {Christine G.} and Nancy Close and Walter Gilliam and Sheila Greisman and Elaine Romano and Joanne Williams",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.jpeds.2016.05.070",
language = "English (US)",
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pages = "62--68.e4",
journal = "Journal of Pediatrics",
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TY - JOUR

T1 - Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth

AU - Navarrete, Cristina T.

AU - Duara, Shahnaz

AU - Wrage, Lisa A.

AU - Gantz, Marie G.

AU - Carlo, Waldemar A.

AU - Walsh, Michele C.

AU - Rich, Wade

AU - Newman, Nancy S.

AU - Das, Abhik

AU - Schibler, Kurt

AU - Piazza, Anthony J.

AU - Poindexter, Brenda B.

AU - Shankaran, Seetha

AU - Sánchez, Pablo J.

AU - Morris, Brenda H.

AU - Frantz, Ivan D.

AU - Van Meurs, Krisa P.

AU - Cotten, C. Michael

AU - Ehrenkranz, Richard A.

AU - Bell, Edward F.

AU - Watterberg, Kristi L.

AU - Higgins, Rosemary D.

AU - Das, Abhik

AU - Gantz, Marie

AU - Jobe, Alan H.

AU - Caplan, Michael S.

AU - Fanaroff, Avroy A.

AU - Wilson-Costello, Deanne E.

AU - Siner, Bonnie S.

AU - Zadell, Arlene

AU - DiFiore, Julie

AU - Bhola, Monika

AU - Friedman, Harriet G.

AU - Yalcinkaya, Gulgun

AU - Donovan, Edward F.

AU - Narendran, Vivek

AU - Yolton, Kimberly

AU - Bridges, Kate

AU - Alexander, Barbara

AU - Grisby, Cathy

AU - Mersmann, Marcia Worley

AU - Mincey, Holly L.

AU - Hessling, Jody

AU - Gratton, Teresa L.

AU - Goldberg, Ronald N.

AU - Goldstein, Ricki F.

AU - Ashley, Patricia

AU - Auten, Kathy J.

AU - Fisher, Kimberley A.

AU - Foy, Katherine A.

AU - Freedman, Sharon F.

AU - Gustafson, Kathryn E.

AU - Lohmeyer, Melody B.

AU - Malcolm, William F.

AU - Wallace, David K.

AU - Stoll, Barbara J.

AU - Adams-Chapman, Ira

AU - Buchter, Susie

AU - Carlton, David P.

AU - Carter, Sheena

AU - Fritz, Sobha

AU - Hale, Ellen C.

AU - Hutchinson, Amy K.

AU - LaRossa, Maureen Mulligan

AU - Smikle, Gloria V.

AU - Archer, Stephanie Wilson

AU - Dusick, Anna M.

AU - Lemons, James A.

AU - Myers, Gary J.

AU - Wilson, Leslie D.

AU - Hamer, Faithe

AU - Cook, Ann B.

AU - Herron, Dianne E.

AU - Lytle, Carolyn

AU - Minnich, Heike M.

AU - Berberich, Mary Anne

AU - Blaisdell, Carol J.

AU - Gail, Dorothy B.

AU - Kiley, James P.

AU - Poole, W. Kenneth

AU - Newman, Jamie E.

AU - Hastings, Betty K.

AU - O'Donnell Auman, Jeanette

AU - Huitema, Carolyn Petrie

AU - Pickett, James W.

AU - Wallace, Dennis

AU - Zaterka-Baxter, Kristin M.

AU - Stevenson, David K.

AU - Hintz, Susan R.

AU - Ball, M. Bethany

AU - Bentley, Barbara

AU - Bruno, Elizabeth F.

AU - Davis, Alexis S.

AU - DeAnda, Maria Elena

AU - DeBattista, Anne M.

AU - Huffman, Lynne C.

AU - Kohn, Jean G.

AU - Proud, Melinda S.

AU - Pyle, Renee P.

AU - John, Nicholas

AU - Weiss, Hali E.

AU - Fiascone, John M.

AU - McGowan, Elisabeth C.

AU - Furey, Anne

AU - MacKinnon, Brenda L.

AU - Nylen, Ellen

AU - Brussa, Ana

AU - Sibley, Cecelia

AU - Ambalavanan, Namasivayam

AU - Peralta-Carcelen, Myriam

AU - Collins, Monica V.

AU - Cosby, Shirley S.

AU - Phillips, Vivien A.

AU - Bailey, Kirstin J.

AU - Biasini, Fred J.

AU - Hopkins, Maria

AU - Johnston, Kristen C.

AU - Krzywanski, Sara

AU - Nelson, Kathleen G.

AU - Patterson, Cryshelle S.

AU - Rector, Richard V.

AU - Rodriguez, Leslie

AU - Soong, Amanda

AU - Whitley, Sally

AU - York, Sheree

AU - Widness, John A.

AU - Acarregui, Michael J.

AU - Klein, Jonathan M.

AU - Colaizy, Tarah T.

AU - Johnson, Karen J.

AU - Eastman, Diane L.

AU - Bauer, Charles R.

AU - Everett-Thomas, Ruth

AU - Calejo, Maria

AU - Diaz, Alexis N.

AU - Frade Eguaras, Silvia M.

AU - Garcia, Andrea

AU - Hamlin-Smith, Kasey

AU - Berkowits, Michelle Harwood

AU - Hiriart-Fajardo, Sylvia

AU - Pierre, Helina

AU - Rigaud, Arielle

AU - Stroerger, Alexandra

AU - Ohls, Robin K.

AU - Fuller, Janell

AU - Rohr, Julie

AU - Lacy, Conra Backstrom

AU - Lowe, Jean

AU - Montman, Rebecca

AU - Brion, Luc

AU - Rosenfeld, Charles R.

AU - Salhab, Walid A.

AU - Heyne, Roy J.

AU - Adams, Sally S.

AU - Allen, James

AU - Chen, Lijun

AU - Grau, Laura

AU - Guzman, Alicia

AU - Hensley, Gaynelle

AU - Heyne, Elizabeth T.

AU - Hickman, Jackie

AU - Lepps, Melissa H.

AU - Madden, Linda A.

AU - Miller, Nancy A.

AU - Morgan, Janet S.

AU - Solis, Araceli

AU - Torres, Lizette E.

AU - Boatman, Catherine Twell

AU - Vasil, Diana M.

AU - Kennedy, Kathleen A.

AU - Tyson, Jon E.

AU - Akpa, Esther G.

AU - Alaniz, Nora I.

AU - Dieterich, Susan

AU - Evans, Patricia W.

AU - Green, Charles

AU - Harris, Beverly Foley

AU - Jiminez, Margarita

AU - Lis, Anna E.

AU - Martin, Karen

AU - Martin, Sarah

AU - McDavid, Georgia E.

AU - Morris, Brenda H.

AU - Poundstone, M. Layne

AU - Reddoch, Stacey

AU - Siddiki, Saba

AU - Simmons, Maegan C.

AU - Pierce Tate, Patti L.

AU - Wright, Sharon L.

AU - Sood, Beena G.

AU - Pappas, Athina

AU - Bara, Rebecca

AU - Billian, Elizabeth

AU - Goldston, Laura A.

AU - Johnson, Mary

AU - Bhandari, Vineet

AU - Jacobs, Harris C.

AU - Cervone, Pat

AU - Gettner, Patricia

AU - Konstantino, Monica

AU - Poulsen, Jo Ann

AU - Taft, Janet

AU - Butler, Christine G.

AU - Close, Nancy

AU - Gilliam, Walter

AU - Greisman, Sheila

AU - Romano, Elaine

AU - Williams, Joanne

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objective To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. Study design We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression. Results Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups. Conclusion Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.

AB - Objective To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age. Study design We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression. Results Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups. Conclusion Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.

KW - ELBW growth

KW - oxygen saturation target

UR - http://www.scopus.com/inward/record.url?scp=85006409750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006409750&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2016.05.070

DO - 10.1016/j.jpeds.2016.05.070

M3 - Article

VL - 176

SP - 62-68.e4

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -