Growth rates of small cell bronchogenic carcinomas

B. A. Brigham, P. A. Bunn, J. D. Minna, M. H. Cohen, D. C. Ihde, S. E. Shackney

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In reviewing a series of 144 patients with small cell bronchogenic carcinoma, 12 were found to have serially measurable roentgenographic lesions prior to therapy. Although caliper-based measurements and a silhouette cutout method gave comparable sets of tumor doubling time data, inter-observer variability was less with the silhouette cutout method. Tumor doubling times in small cell bronchogenic carcinoma ranged between 25 and 160 days, with a median of 77 days, a log mean of 81 days, and an arithmetic mean of 91 days. There was no apparent relation between tumor doubling time and tumor location, histologic subtype, response to therapy, or patient survival. The data indicate that small cell bronchogenic carcinoma of the lung is a relatively slowly growing tumor. Assuming that late subclinical disease exhibits growth characteristics that are similar to those seen in the clinical stages of growth, it can be estimated that residual body tumor burdens of 1 x 10 6 cells may be followed by tumor recurrence times of 2 years or longer; the likelihood of 'cure' should not be entertained in patients with disease-free intervals shorter than 4-5 years.

Original languageEnglish (US)
Pages (from-to)2880-2886
Number of pages7
JournalCancer
Volume42
Issue number6
StatePublished - 1978

Fingerprint

Small Cell Carcinoma
Bronchogenic Carcinoma
Growth
Neoplasms
Body Burden
Observer Variation
Residual Neoplasm
Tumor Burden
Recurrence
Lung
Survival
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Brigham, B. A., Bunn, P. A., Minna, J. D., Cohen, M. H., Ihde, D. C., & Shackney, S. E. (1978). Growth rates of small cell bronchogenic carcinomas. Cancer, 42(6), 2880-2886.

Growth rates of small cell bronchogenic carcinomas. / Brigham, B. A.; Bunn, P. A.; Minna, J. D.; Cohen, M. H.; Ihde, D. C.; Shackney, S. E.

In: Cancer, Vol. 42, No. 6, 1978, p. 2880-2886.

Research output: Contribution to journalArticle

Brigham, BA, Bunn, PA, Minna, JD, Cohen, MH, Ihde, DC & Shackney, SE 1978, 'Growth rates of small cell bronchogenic carcinomas', Cancer, vol. 42, no. 6, pp. 2880-2886.
Brigham BA, Bunn PA, Minna JD, Cohen MH, Ihde DC, Shackney SE. Growth rates of small cell bronchogenic carcinomas. Cancer. 1978;42(6):2880-2886.
Brigham, B. A. ; Bunn, P. A. ; Minna, J. D. ; Cohen, M. H. ; Ihde, D. C. ; Shackney, S. E. / Growth rates of small cell bronchogenic carcinomas. In: Cancer. 1978 ; Vol. 42, No. 6. pp. 2880-2886.
@article{191ed81c8b334ee4931253b2e9f09d98,
title = "Growth rates of small cell bronchogenic carcinomas",
abstract = "In reviewing a series of 144 patients with small cell bronchogenic carcinoma, 12 were found to have serially measurable roentgenographic lesions prior to therapy. Although caliper-based measurements and a silhouette cutout method gave comparable sets of tumor doubling time data, inter-observer variability was less with the silhouette cutout method. Tumor doubling times in small cell bronchogenic carcinoma ranged between 25 and 160 days, with a median of 77 days, a log mean of 81 days, and an arithmetic mean of 91 days. There was no apparent relation between tumor doubling time and tumor location, histologic subtype, response to therapy, or patient survival. The data indicate that small cell bronchogenic carcinoma of the lung is a relatively slowly growing tumor. Assuming that late subclinical disease exhibits growth characteristics that are similar to those seen in the clinical stages of growth, it can be estimated that residual body tumor burdens of 1 x 10 6 cells may be followed by tumor recurrence times of 2 years or longer; the likelihood of 'cure' should not be entertained in patients with disease-free intervals shorter than 4-5 years.",
author = "Brigham, {B. A.} and Bunn, {P. A.} and Minna, {J. D.} and Cohen, {M. H.} and Ihde, {D. C.} and Shackney, {S. E.}",
year = "1978",
language = "English (US)",
volume = "42",
pages = "2880--2886",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Growth rates of small cell bronchogenic carcinomas

AU - Brigham, B. A.

AU - Bunn, P. A.

AU - Minna, J. D.

AU - Cohen, M. H.

AU - Ihde, D. C.

AU - Shackney, S. E.

PY - 1978

Y1 - 1978

N2 - In reviewing a series of 144 patients with small cell bronchogenic carcinoma, 12 were found to have serially measurable roentgenographic lesions prior to therapy. Although caliper-based measurements and a silhouette cutout method gave comparable sets of tumor doubling time data, inter-observer variability was less with the silhouette cutout method. Tumor doubling times in small cell bronchogenic carcinoma ranged between 25 and 160 days, with a median of 77 days, a log mean of 81 days, and an arithmetic mean of 91 days. There was no apparent relation between tumor doubling time and tumor location, histologic subtype, response to therapy, or patient survival. The data indicate that small cell bronchogenic carcinoma of the lung is a relatively slowly growing tumor. Assuming that late subclinical disease exhibits growth characteristics that are similar to those seen in the clinical stages of growth, it can be estimated that residual body tumor burdens of 1 x 10 6 cells may be followed by tumor recurrence times of 2 years or longer; the likelihood of 'cure' should not be entertained in patients with disease-free intervals shorter than 4-5 years.

AB - In reviewing a series of 144 patients with small cell bronchogenic carcinoma, 12 were found to have serially measurable roentgenographic lesions prior to therapy. Although caliper-based measurements and a silhouette cutout method gave comparable sets of tumor doubling time data, inter-observer variability was less with the silhouette cutout method. Tumor doubling times in small cell bronchogenic carcinoma ranged between 25 and 160 days, with a median of 77 days, a log mean of 81 days, and an arithmetic mean of 91 days. There was no apparent relation between tumor doubling time and tumor location, histologic subtype, response to therapy, or patient survival. The data indicate that small cell bronchogenic carcinoma of the lung is a relatively slowly growing tumor. Assuming that late subclinical disease exhibits growth characteristics that are similar to those seen in the clinical stages of growth, it can be estimated that residual body tumor burdens of 1 x 10 6 cells may be followed by tumor recurrence times of 2 years or longer; the likelihood of 'cure' should not be entertained in patients with disease-free intervals shorter than 4-5 years.

UR - http://www.scopus.com/inward/record.url?scp=0018232289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018232289&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 2880

EP - 2886

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 6

ER -