Guanylin and uroguanylin: Intestinal peptide hormones that regulate epithelial transport

Leonard R. Forte, F. Kent Hamra

Research output: Contribution to journalArticle

46 Scopus citations


Guanylin and uroguanylin are peptides that activate a membrane guanylate cyclase and control salt and water transport. Intestinal bacteria secrete toxins that mimic the actions of these peptides, causing a secretory form of diarrhea. Stimulation of guanylin/uroguanylin receptors in the kidney increases salt excretion. Thus guanylin and uroguanylin may regulate salt and water homeostasis.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalNews in Physiological Sciences
Issue number1
StatePublished - Feb 1 1996


ASJC Scopus subject areas

  • Physiology

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