Guanylin and uroguanylin: Intestinal peptide hormones that regulate epithelial transport

Leonard R. Forte, F. Kent Hamra

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Guanylin and uroguanylin are peptides that activate a membrane guanylate cyclase and control salt and water transport. Intestinal bacteria secrete toxins that mimic the actions of these peptides, causing a secretory form of diarrhea. Stimulation of guanylin/uroguanylin receptors in the kidney increases salt excretion. Thus guanylin and uroguanylin may regulate salt and water homeostasis.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalNews in Physiological Sciences
Volume11
Issue number1
StatePublished - Feb 1996

Fingerprint

Gastrointestinal Hormones
Peptide Hormones
Salts
Peptides
Water
Guanylate Cyclase
Diarrhea
Homeostasis
Bacteria
Kidney
Membranes
guanylin
uroguanylin

ASJC Scopus subject areas

  • Physiology

Cite this

Guanylin and uroguanylin : Intestinal peptide hormones that regulate epithelial transport. / Forte, Leonard R.; Hamra, F. Kent.

In: News in Physiological Sciences, Vol. 11, No. 1, 02.1996, p. 17-24.

Research output: Contribution to journalArticle

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